Gut microbiome at the crossroad of genetic variants and behavior disorders
L Cheng, H Wu, Z Chen, H Hao, X Zheng - Gut Microbes, 2023 - Taylor & Francis
Genetic variants are traditionally known to shape the susceptibility to neuropsychiatric
disorders. An increasing number of studies indicate that remodeling of the gut microbiome …
disorders. An increasing number of studies indicate that remodeling of the gut microbiome …
[HTML][HTML] The impact of rare protein coding genetic variation on adult cognitive function
Compelling evidence suggests that human cognitive function is strongly influenced by
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …
genetics. Here, we conduct a large-scale exome study to examine whether rare protein …
[HTML][HTML] Genomic findings in schizophrenia and their implications
There has been substantial progress in understanding the genetics of schizophrenia over
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
the past 15 years. This has revealed a highly polygenic condition with the majority of the …
Genome-wide association analyses identify 95 risk loci and provide insights into the neurobiology of post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability
than most other psychiatric disorders. The contribution to biological understanding from …
than most other psychiatric disorders. The contribution to biological understanding from …
Multi-omics data integration methods and their applications in psychiatric disorders
To study mental illness and health, in the past researchers have often broken down their
complexity into individual subsystems (eg, genomics, transcriptomics, proteomics, clinical …
complexity into individual subsystems (eg, genomics, transcriptomics, proteomics, clinical …
[PDF][PDF] Joint analysis of GWAS and multi-omics QTL summary statistics reveals a large fraction of GWAS signals shared with molecular phenotypes
Molecular quantitative trait loci (xQTLs) are often harnessed to prioritize genes or functional
elements underpinning variant-trait associations identified from genome-wide association …
elements underpinning variant-trait associations identified from genome-wide association …
Improving fine-mapping by modeling infinitesimal effects
Fine-mapping aims to identify causal genetic variants for phenotypes. Bayesian fine-
mapping algorithms (for example, SuSiE, FINEMAP, ABF and COJO-ABF) are widely used …
mapping algorithms (for example, SuSiE, FINEMAP, ABF and COJO-ABF) are widely used …
[HTML][HTML] Transcriptional linkage analysis with in vivo AAV-Perturb-seq
The ever-growing compendium of genetic variants associated with human pathologies
demands new methods to study genotype–phenotype relationships in complex tissues in a …
demands new methods to study genotype–phenotype relationships in complex tissues in a …
[HTML][HTML] Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease
J Lake, C Warly Solsberg, JJ Kim, J Acosta-Uribe… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …
out in European ancestry individuals despite the known variation in genetic architecture and …
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA‐MeDALL hypothesis
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …
overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over …