Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions

KP de Arce, A Ribic, D Chowdhury, K Watters… - Nature …, 2023 - nature.com
Multiple trans-synaptic complexes organize synapse development, yet their roles in the
mature brain and cooperation remain unclear. We analyzed the postsynaptic adhesion …

Meta-analyses of genome-wide association studies for postpartum depression

J Guintivano, EM Byrne, J Kiewa… - American Journal of …, 2023 - Am Psychiatric Assoc
Objective: Postpartum depression (PPD) is a common subtype of major depressive disorder
(MDD) that is more heritable, yet is understudied in psychiatric genetics. The authors …

The molecular pathology of schizophrenia: An overview of existing knowledge and new directions for future research

T Nakamura, A Takata - Molecular Psychiatry, 2023 - nature.com
Despite enormous efforts employing various approaches, the molecular pathology in the
schizophrenia brain remains elusive. On the other hand, the knowledge of the association …

Rare tandem repeat expansions associate with genes involved in synaptic and neuronal signaling functions in schizophrenia

J Wen, B Trost, W Engchuan, M Halvorsen… - Molecular …, 2023 - nature.com
Tandem repeat expansions (TREs) are associated with over 60 monogenic disorders and
have recently been implicated in complex disorders such as cancer and autism spectrum …

The relationship between cannabis use, schizophrenia, and bipolar disorder: a genetically informed study

W Cheng, N Parker, N Karadag, E Koch… - The Lancet …, 2023 - thelancet.com
Background The relationship between psychotic disorders and cannabis use is heavily
debated. Shared underlying genetic risk is one potential explanation. We investigated the …

Co‐development of attention deficit hyperactivity disorder and autistic trait trajectories from childhood to early adulthood

A Shakeshaft, J Heron, R Blakey… - Journal of Child …, 2023 - Wiley Online Library
Background Attention deficit hyperactivity disorder (ADHD) and autism, defined as traits or
disorders, commonly co‐occur. Developmental trajectories of ADHD and autistic traits both …

[PDF][PDF] Brain-region-specific changes in neurons and glia and dysregulation of dopamine signaling in Grin2a mutant mice

Z Farsi, A Nicolella, SK Simmons, S Aryal, N Shepard… - Neuron, 2023 - cell.com
A genetically valid animal model could transform our understanding of schizophrenia (SCZ)
disease mechanisms. Rare heterozygous loss-of-function (LoF) mutations in GRIN2A …

Targeting NMDA receptors at the neurovascular unit: Past and future treatments for central nervous system diseases

C Seillier, F Lesept, O Toutirais, F Potzeha… - International journal of …, 2022 - mdpi.com
The excitatory neurotransmission of the central nervous system (CNS) mainly involves
glutamate and its receptors, especially N-methyl-D-Aspartate receptors (NMDARs). These …

Addressing the ethical and societal challenges posed by genome-wide association studies of behavioral and brain-related traits

MC de Hemptinne, D Posthuma - Nature neuroscience, 2023 - nature.com
Genome-wide association studies have led to the identification of robust statistical
associations of genetic variants with numerous brain-related traits, including neurological …

Wrestling with social and behavioral genomics: risks, potential benefits, and ethical responsibility

MN Meyer, PS Appelbaum, DJ Benjamin… - Hastings Center …, 2023 - Wiley Online Library
In this consensus report by a diverse group of academics who conduct and/or are concerned
about social and behavioral genomics (SBG) research, the authors recount the often‐ugly …