Alternative splicing is a substantial contributor to the high complexity of transcriptomes of multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of …
A major goal of evolutionary genetics is to understand the genetic processes that give rise to phenotypic diversity in multicellular organisms. Alternative splicing generates multiple …
An average shotgun proteomics experiment detects approximately 10,000 human proteins from a single sample. However, individual proteins are typically identified by peptide …
Covalently closed, single-stranded circular RNAs can be produced from viral RNA genomes as well as from the processing of cellular housekeeping noncoding RNAs and precursor …
The removal of introns from mRNA precursors and its regulation by alternative splicing are key for eukaryotic gene expression and cellular function, as evidenced by the numerous …
Background Splicing of genomic exons into mRNAs is a critical prerequisite for the accurate synthesis of human proteins. Genetic variants impacting splicing underlie a substantial …
The aim of the UniProt Knowledgebase is to provide users with a comprehensive, high- quality and freely accessible set of protein sequences annotated with functional information …
While the processing of mRNA is essential for gene expression, recent findings have highlighted that RNA processing is systematically altered in cancer. Mutations in RNA …
H Wu, RG Villalobos, X Yao, D Reilly, T Chen… - Cell metabolism, 2022 - cell.com
Diabetic kidney disease (DKD) occurs in∼ 40% of patients with diabetes and causes kidney failure, cardiovascular disease, and premature death. We analyzed the response of a …