Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …

Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …

The DNA damage response (DDR) is an organized network of multiple interwoven
components evolved to repair damaged DNA and maintain genome fidelity. Conceptually …

Mitochondria are increasingly recognized as cellular hubs to orchestrate signaling pathways
that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research …

Control of excessive mitochondrial oxidative stress could provide new targets for both
preventive and therapeutic interventions in the treatment of chronic inflammation or any …

Childhood obesity is a serious public health crisis and a critical factor that determines future
obesity prevalence. Signals affecting adipocyte development in early postnatal life have a …

Parkinson's disease (PD) is a common neurodegenerative condition for which no approved
treatment exists to prevent collective neuronal death. There is ample evidence that …

Researchers from diverse disciplines, including organismal and cellular physiology, sports
science, human nutrition, evolution and ecology, have sought to understand the causes and …

Inflammasomes are multiprotein signaling platforms in the cytosol that senses exogenous
and endogenous danger signals and respond with the maturation and secretion of IL-1β and …