A natural products solution to diabetic nephropathy therapy
Q Hu, L Jiang, Q Yan, J Zeng, X Ma, Y Zhao - Pharmacology & Therapeutics, 2023 - Elsevier
Diabetic nephropathy is one of the most common complications in diabetes. It has been
shown to be the leading cause of end-stage renal disease. However, due to their complex …
shown to be the leading cause of end-stage renal disease. However, due to their complex …
Molecular mechanisms of diabetic kidney disease
J Rico-Fontalvo, G Aroca, J Cabrales… - International Journal of …, 2022 - mdpi.com
The inflammatory component of diabetic kidney disease has become of great interest in
recent years, with genetic and epigenetic variants playing a fundamental role in the initiation …
recent years, with genetic and epigenetic variants playing a fundamental role in the initiation …
Long non-coding RNA DLX6-AS1 is the key mediator of glomerular podocyte injury and albuminuria in diabetic nephropathy by targeting the miR-346/GSK-3β …
J Guo, W Zheng, Y Liu, M Zhou, Y Shi, M Lei… - Cell death & …, 2023 - nature.com
Progressive albuminuria is the primary clinical symptom of diabetic nephropathy (DN),
leading to a gradual decline in kidney function. DLX6-AS1 was the first reported long non …
leading to a gradual decline in kidney function. DLX6-AS1 was the first reported long non …
Role of MCP-1 as an inflammatory biomarker in nephropathy
Y Liu, K Xu, Y Xiang, B Ma, H Li, Y Li, Y Shi… - Frontiers in …, 2024 - frontiersin.org
The Monocyte chemoattractant protein-1 (MCP-1), also referred to as chemokine ligand 2
(CCL2), belongs to the extensive chemokine family and serves as a crucial mediator of …
(CCL2), belongs to the extensive chemokine family and serves as a crucial mediator of …
Estimated small dense low-density lipoprotein-cholesterol and the risk of kidney and cardiovascular outcomes in diabetic kidney disease
Q Yang, Y Zou, Y Lang, J Yang, Y Wu, X Xiao, C Qin… - Renal …, 2024 - Taylor & Francis
Aims This study aimed to investigate the correlations between estimated small dense low-
density lipoprotein-cholesterol (esd-LDL-c) and the development of end-stage kidney …
density lipoprotein-cholesterol (esd-LDL-c) and the development of end-stage kidney …
Regulation of monocytes/macrophages by the renin–angiotensin system in diabetic nephropathy: State of the art and results of a pilot study
C Moratal, A Laurain, M Naïmi, T Florin… - International Journal of …, 2021 - mdpi.com
Diabetic nephropathy (DN) is characterized by albuminuria, loss of renal function, renal
fibrosis and infiltration of macrophages originating from peripheral monocytes inside …
fibrosis and infiltration of macrophages originating from peripheral monocytes inside …
Ombuin ameliorates diabetic nephropathy in rats by anti‐inflammation and antifibrosis involving Notch 1 and PPAR γ signaling pathways
B Liu, C Deng, P Tan - Drug Development Research, 2022 - Wiley Online Library
Diabetic nephropathy (DN) is a common complication of diabetes and it is urgent to develop
effective therapies for DN. In this study, high‐sucrose and high‐fat diet combined with …
effective therapies for DN. In this study, high‐sucrose and high‐fat diet combined with …
ESRRA modulation by empagliflozin mitigates diabetic tubular injury via mitochondrial restoration
K Yang, W Liang, H Hu, Z Zhang, Y Hao, Z Song… - Cellular …, 2024 - Elsevier
Background The protection of the diabetic kidney by Empagliflozin (EMPA) is attributed to its
interaction with the sodium glucose cotransporter 2 located on proximal tubular epithelial …
interaction with the sodium glucose cotransporter 2 located on proximal tubular epithelial …
Targeting Pyroptosis: New Insights into the Treatment of Diabetic Microvascular Complications
J Gu, K Geng, M Guo, W Huang, T Zhao… - Evidence‐Based …, 2022 - Wiley Online Library
Pyroptosis is an inflammatory form of programmed cell death that is dependent on
inflammatory caspases, leading to the cleavage of gasdermin D (GSDMD) and increased …
inflammatory caspases, leading to the cleavage of gasdermin D (GSDMD) and increased …
Differences and Clinical Significance of Serum 25-Hydroxyvitamin D3 and Vasohibin-1 (VASH-1) Levels in Patients with Diabetic Nephropathy and Different Renal …
H Liu, D Wang, J Tang, L Yu, S Su - Diabetes, Metabolic Syndrome …, 2023 - Taylor & Francis
Objective We investigate the relationship between the changes of serum 25-hydroxyvitamin
D3 (25 (OH) D3) and vasohibin-1 (VASH-1) and renal function injury in patients with type 2 …
D3 (25 (OH) D3) and vasohibin-1 (VASH-1) and renal function injury in patients with type 2 …