Misdirected sympathy: the role of sympatholysis in sepsis and septic shock
JA Ferreira, BD Bissell - Journal of Intensive Care Medicine, 2018 - journals.sagepub.com
The spectrum of sepsis and septic shock remains a highly prevalent disease state, carrying
a high risk of morbidity and mortality. The sympathetic nervous system (SNS) plays an …
a high risk of morbidity and mortality. The sympathetic nervous system (SNS) plays an …
Heart rate reduction with esmolol is associated with improved arterial elastance in patients with septic shock: a prospective observational study
Abstract Purpose Ventricular–arterial (V–A) decoupling decreases myocardial efficiency and
is exacerbated by tachycardia that increases static arterial elastance (Ea). We thus …
is exacerbated by tachycardia that increases static arterial elastance (Ea). We thus …
Ultra-short–acting β-blockers (Esmolol and Landiolol) in the perioperative period and in critically ill patients
R Poveda-Jaramillo, F Monaco, A Zangrillo… - … of Cardiothoracic and …, 2018 - Elsevier
β-Blockers are useful drugs in several clinical cardiologic scenarios. Their use in the
perioperative period and in critically ill patients is increasing, but their effect on clinically …
perioperative period and in critically ill patients is increasing, but their effect on clinically …
Randomized clinical trial of landiolol hydrochloride for the prevention of atrial fibrillation and postoperative complications after oesophagectomy for cancer
T Ojima, M Nakamori, M Nakamura… - Journal of British …, 2017 - academic.oup.com
Background Atrial fibrillation is common after oesophageal surgery. The aim of this study
was to evaluate whether landiolol hydrochloride was effective and safe in the prevention of …
was to evaluate whether landiolol hydrochloride was effective and safe in the prevention of …
Landiolol hydrochloride ameliorates acute lung injury in a rat model of early sepsis through the suppression of elevated levels of pulmonary endothelin-1
Y Matsuishi, S Jesmin, S Kawano, S Hideaki… - Life sciences, 2016 - Elsevier
Among the dysfunctions and pathologies associated with sepsis, the underlying molecular
mechanisms of sepsis-induced acute lung injury (ALI) are poorly understood. Endothelin …
mechanisms of sepsis-induced acute lung injury (ALI) are poorly understood. Endothelin …
Landiolol for managing atrial fibrillation in intensive care
S Rehberg, M Joannidis, T Whitehouse… - European Heart …, 2018 - academic.oup.com
Landiolol is an injectable ultrashort acting beta-blocker with high beta1 selectivity indicated
for heart rate control of atrial fibrillation in the emergency and critical care setting …
for heart rate control of atrial fibrillation in the emergency and critical care setting …
[HTML][HTML] Landiolol in patients with septic shock resident in an intensive care unit (LANDI-SEP): study protocol for a randomized controlled trial
Background In patients with septic shock, the presence of an elevated heart rate (HR) after
fluid resuscitation marks a subgroup of patients with a particularly poor prognosis. Several …
fluid resuscitation marks a subgroup of patients with a particularly poor prognosis. Several …
[HTML][HTML] An Overview of the Pharmacokinetics and Pharmacodynamics of Landiolol (an Ultra-Short Acting β1 Selective Antagonist) in Atrial Fibrillation
Landiolol is an ultra-short-acting, selective β1-adrenergic receptor blocker that was
originally approved in Japan for the treatment of intraoperative tachyarrhythmias. It has …
originally approved in Japan for the treatment of intraoperative tachyarrhythmias. It has …
Evaluating the therapeutic efficacy and safety of landiolol hydrochloride for management of arrhythmia in critical settings: review of the literature
Y Matsuishi, BJ Mathis, N Shimojo… - Vascular health and …, 2020 - Taylor & Francis
Background Landiolol hydrochloride, a highly cardio-selective beta-1 blocker with an ultra-
short-acting half-life of 4 minutes, was originally approved by Japan for treatment of …
short-acting half-life of 4 minutes, was originally approved by Japan for treatment of …
Study into the reversal of septic shock with landiolol (beta blockade): STRESS-L Study protocol for a randomised trial
Introduction In 2013, a single-centre study reported the safe use of esmolol in patients with
septic shock and tachycardia who required vasopressor therapy for more than 24 hours …
septic shock and tachycardia who required vasopressor therapy for more than 24 hours …