Targeting oncogenic signaling in mutant FLT3 acute myeloid leukemia: the path to least resistance
The identification of recurrent driver mutations in genes encoding tyrosine kinases has
resulted in the development of molecularly-targeted treatment strategies designed to …
resulted in the development of molecularly-targeted treatment strategies designed to …
Quizartinib (AC220): a promising option for acute myeloid leukemia
F Zhou, Z Ge, B Chen - Drug design, development and therapy, 2019 - Taylor & Francis
Quizartinib is an effective therapy for patients with FLT3-ITD acute myeloid leukemia (AML)
by continuing to inhibit the activity of FLT3 gene, leading to apoptosis of tumor cells. Multiple …
by continuing to inhibit the activity of FLT3 gene, leading to apoptosis of tumor cells. Multiple …
The PGRS domain of Mycobacterium tuberculosis PE_PGRS protein Rv0297 is involved in endoplasmic reticulum stress-mediated apoptosis through toll-like receptor …
The genome of Mycobacterium tuberculosis, the causal organism of tuberculosis (TB),
encodes a unique protein family known as the PE/PPE/PGRS family, present exclusively in …
encodes a unique protein family known as the PE/PPE/PGRS family, present exclusively in …
Comparative transcriptomic and proteomic analysis of the antibacterial activity of emodin on Aeromonas hydrophila
Aeromonas hydrophila is one of the main pathogens in aquaculture. Our previous studies
have shown that emodin could inhibit the proliferation of A. hydrophila, however, the …
have shown that emodin could inhibit the proliferation of A. hydrophila, however, the …
[HTML][HTML] Understanding mechanisms of resistance to FLT3 inhibitors in adult FLT3-mutated Acute Myeloid Leukemia (AML) to guide treatment strategy
M Ruglioni, S Crucitta, GI Luculli, G Tancredi… - Critical Reviews in …, 2024 - Elsevier
The presence of FLT3 mutations, including the most common FLT3-ITD (internal tandem
duplications) and FLT3-TKD (tyrosine kinase domain), is associated with an unfavorable …
duplications) and FLT3-TKD (tyrosine kinase domain), is associated with an unfavorable …
Insights Into the Resistance Mechanisms of Inhibitors to FLT3 F691L Mutation via an Integrated Computational Approach
Y Sun, Z Xia, Q Zhao, B Zheng, M Zhang… - Frontiers in …, 2019 - frontiersin.org
Research has shown that FMS-like tyrosine kinase 3 (FLT3) may be a vital drug target for
acute myeloid leukemia (AML). However, even though the clinically relevant F691L …
acute myeloid leukemia (AML). However, even though the clinically relevant F691L …
[PDF][PDF] “The” Role of the Cancer Kinome in the Healthy and Injured Heart: Focus on Flt3 and Plk2
DM Belik - 2022 - e-helvetica.nb.admin.ch
In this work we investigated the effects of the Fms-like tyrosine kinase 3 (Flt3) targeting
inhibitor quizartinib in the infarcted mouse heart. Flt3 is a transmembrane receptor tyrosine …
inhibitor quizartinib in the infarcted mouse heart. Flt3 is a transmembrane receptor tyrosine …
[PDF][PDF] ISOLATION, OVEREXPRESSION AND CHARACTERIZATION OF AN
K BATUMALAIE - 2018 - core.ac.uk
The study reports the purification and comprehensive biochemical characterization of a
novel lipase KV1 (LipKV1) from Acinetobacter haemolyticus strain KV1. Strain KV1 was …
novel lipase KV1 (LipKV1) from Acinetobacter haemolyticus strain KV1. Strain KV1 was …