L Wang, L Yang, C Wang, W Zhao, Z Ju… - The Journal of …, 2020 - Am Soc Clin Investig
ARID1A, a component of the chromatin-remodeling complex SWI/SNF, is one of the most frequently mutated genes in human cancer. We sought to develop rational combination …
AJ Morrison - … Transactions of the Royal Society B …, 2017 - royalsocietypublishing.org
Chromatin modification is conserved in all eukaryotes and is required to facilitate and regulate DNA-templated processes. For example, chromatin manipulation, such as histone …
J Poli, CB Gerhold, A Tosi, N Hustedt… - Genes & …, 2016 - genesdev.cshlp.org
Little is known about how cells ensure DNA replication in the face of RNA polymerase II (RNAPII)-mediated transcription, especially under conditions of replicative stress. Here we …
P Sen, J Luo, A Hada, SG Hailu, ML Dechassa… - Cell Reports, 2017 - cell.com
The SWI/SNF chromatin remodeling complex is highly conserved from yeast to human, and aberrant SWI/SNF complexes contribute to human disease. The Snf5/SMARCB1/INI1 …
X Wang, T Ran, X Zhang, J Xin, Z Zhang, T Wu… - Science, 2017 - science.org
The ataxia telangiectasia–mutated and Rad3-related (ATR) kinase is a master regulator of DNA damage response and replication stress in humans, but the mechanism of its activation …
B Jöhnk, Ö Bayram, A Abelmann, T Heinekamp… - PLoS …, 2016 - journals.plos.org
F-box proteins share the F-box domain to connect substrates of E3 SCF ubiquitin RING ligases through the adaptor Skp1/A to Cul1/A scaffolds. F-box protein Fbx15 is part of the …
VN Nikolov, D Malavia, T Kubota - Nature Communications, 2022 - nature.com
Abstract The Pleiotropic Drug Resistance (PDR) network is central to the drug response in fungi, and its overactivation is associated with drug resistance. However, gene regulation of …
NE Wiest, S Houghtaling, JC Sanchez… - Nucleic acids …, 2017 - academic.oup.com
DNA double-strand breaks (DSBs) are repaired by either the non-homologous end joining (NHEJ) or homologous recombination (HR) pathway. Pathway choice is determined by the …
I Litwin, T Bakowski, B Szakal, E Pilarczyk… - The EMBO …, 2018 - embopress.org
DNA damage tolerance (DDT) mechanisms facilitate replication resumption and completion when DNA replication is blocked by bulky DNA lesions. In budding yeast, template switching …