Disruption of the intricate gene expression program represents one of major driving factors
for the development, progression and maintenance of human cancer, and is often …

ARID1A, a component of the chromatin-remodeling complex SWI/SNF, is one of the most
frequently mutated genes in human cancer. We sought to develop rational combination …

Chromatin modification is conserved in all eukaryotes and is required to facilitate and
regulate DNA-templated processes. For example, chromatin manipulation, such as histone …

Little is known about how cells ensure DNA replication in the face of RNA polymerase II
(RNAPII)-mediated transcription, especially under conditions of replicative stress. Here we …

The SWI/SNF chromatin remodeling complex is highly conserved from yeast to human, and
aberrant SWI/SNF complexes contribute to human disease. The Snf5/SMARCB1/INI1 …

The ataxia telangiectasia–mutated and Rad3-related (ATR) kinase is a master regulator of
DNA damage response and replication stress in humans, but the mechanism of its activation …

F-box proteins share the F-box domain to connect substrates of E3 SCF ubiquitin RING
ligases through the adaptor Skp1/A to Cul1/A scaffolds. F-box protein Fbx15 is part of the …

Abstract The Pleiotropic Drug Resistance (PDR) network is central to the drug response in
fungi, and its overactivation is associated with drug resistance. However, gene regulation of …

DNA double-strand breaks (DSBs) are repaired by either the non-homologous end joining
(NHEJ) or homologous recombination (HR) pathway. Pathway choice is determined by the …

DNA damage tolerance (DDT) mechanisms facilitate replication resumption and completion
when DNA replication is blocked by bulky DNA lesions. In budding yeast, template switching …