Impact of obesity on COVID-19 patients

W Yu, KE Rohli, S Yang, P Jia - Journal of Diabetes and its Complications, 2021 - Elsevier
With the increasing prevalence of obesity, there is a growing awareness of its impact on
infectious diseases. In past epidemics of influenza A and Middle East respiratory syndrome …

[HTML][HTML] Flavonoids against the SARS-CoV-2 induced inflammatory storm

A Liskova, M Samec, L Koklesova, SM Samuel… - Biomedicine & …, 2021 - Elsevier
The disease severity of COVID-19, especially in the elderly and patients with co-morbidities,
is characterized by hypercytokinemia, an exaggerated immune response associated with an …

The therapeutic efficacy of quercetin in combination with antiviral drugs in hospitalized COVID-19 patients: A randomized controlled trial

M Shohan, R Nashibi, MR Mahmoudian-Sani… - European journal of …, 2022 - Elsevier
In this study, the therapeutic efficacy of quercetin in combination with remdesivir and
favipiravir, were evaluated in severe hospitalized COVID-19 patients. Our main objective …

[HTML][HTML] IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation

F Zhang, JR Mears, L Shakib, JI Beynor, S Shanaj… - Genome Medicine, 2021 - Springer
Background Immunosuppressive and anti-cytokine treatment may have a protective effect for
patients with COVID-19. Understanding the immune cell states shared between COVID-19 …

[HTML][HTML] The role of type I interferons in the pathogenesis and treatment of COVID-19

G Schreiber - Frontiers in immunology, 2020 - frontiersin.org
Type I interferons (IFN-I) were first discovered over 60 years ago in a classical experiment by
Isaacs and Lindenman, who showed that IFN-Is possess antiviral activity. Later, it became …

[HTML][HTML] Protective effect of vitamin D supplementation on COVID-19-related intensive care hospitalization and mortality: definitive evidence from meta-analysis and …

C Argano, R Mallaci Bocchio, G Natoli, S Scibetta… - Pharmaceuticals, 2023 - mdpi.com
Pharmaceuticals | Free Full-Text | Protective Effect of Vitamin D Supplementation on COVID-19-Related
Intensive Care Hospitalization and Mortality: Definitive Evidence from Meta-Analysis and …

SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor

J Zahradník, S Marciano, M Shemesh, E Zoler… - BioRxiv, 2021 - biorxiv.org
SARS-CoV-2 is continually evolving, with more contagious mutations spreading rapidly.
Using in vitro evolution to affinity maturate the receptor-binding domain (RBD) of the spike …

COVID-19 and Sepsis

ZK Tufan, B Kayaaslan, M Mer - Turkish journal of medical …, 2021 - journals.tubitak.gov.tr
The COVID-19 pandemic has created a major alteration in the medical literature including
the sepsis discussion. From the outset of the pandemic, various reports have indicated that …

The Coronavirus pandemic–2022: Viruses, variants & vaccines

M Alexandridi, J Mazej, E Palermo, J Hiscott - Cytokine & growth factor …, 2022 - Elsevier
Since the beginning of the COVID-19 pandemic in 2019–2020, Cytokine & Growth Factor
Reviews has published several Special Issues focused on the biology, pathogenesis and …

[HTML][HTML] Implications of oxidative stress and potential role of mitochondrial dysfunction in COVID-19: therapeutic effects of vitamin D

N de Las Heras, VM Martín Giménez, L Ferder… - Antioxidants, 2020 - mdpi.com
Due to its high degree of contagiousness and like almost no other virus, SARS-CoV-2 has
put the health of the world population on alert. COVID-19 can provoke an acute inflammatory …