Intratumor heterogeneity has been widely reported in human cancers, but our knowledge of
how this genetic diversity emerges over time remains limited. A central challenge in studying …

Head and neck squamous cell carcinoma (HNSCC) is a very aggressive disease with a poor
prognosis for advanced-stage tumors. Recent clinical, genomic, and cellular studies have …

Therapy resistance and tumour relapse after drug therapy are commonly explained by
Darwinian selection of pre-existing drug-resistant, often stem-like cancer cells resulting from …

Cimetidine, the first H 2 receptor antagonist in widespread clinical use, has anti-cancer
properties that have been elucidated in a broad range of pre-clinical and clinical studies for …

Regulatory T (Treg) cells play a crucial role in maintaining peripheral tolerance and
preventing autoimmunity. However, they also represent a major barrier to effective antitumor …

The administration of chemotherapy at reduced doses given at regular, frequent time
intervals, termed 'metronomic'chemotherapy, presents an alternative to standard maximal …

Abstract Purpose of Review Discussion of current strategies targeting the immune system
related to solid tumors with emphasis on head and neck squamous cell carcinoma …

Severe immune suppression is frequent in late-stage tumor patients and promotes tumor
immune evasion and subsequent tumor progression. Regulatory T cells (Treg) are major …

Cancer-related death is a significant health and economic burden worldwide, and some
conventional chemotherapy is associated with limited effectiveness in completely curing …

Cancer has become one of the most difficult health challenges of our time, accounting for
millions of deaths yearly. Systemic chemotherapy is the most common therapeutic approach; …