Interleukin-12 (IL-12) is a potent, pro-inflammatory type 1 cytokine that has long been
studied as a potential immunotherapy for cancer. Unfortunately, IL-12's remarkable …

This review summarizes the use of high-voltage electrical pulses (HVEPs) in clinical
oncology to treat solid tumors with irreversible electroporation (IRE) and …

Simple Summary Pancreatic cancer remains a major therapeutic challenge despite medical
advances. The incidence of pancreatic cancer is increasing, and this disease is associated …

Several minimally invasive image guided tumor ablation techniques have been added to the
treatment spectrum for locally advanced pancreatic cancer (LAPC). Irreversible …

Pancreatic cancer has no symptoms until the disease has advanced and is aggressive
cancer with early metastasis. Up to now, the only curative treatment is surgical resection …

Background Pancreatic ductal adenocarcinoma is an aggressive disease with a dismal
prognosis. Stage III locally advanced pancreatic cancer is considered unresectable and …

Locally advanced pancreatic cancer (LAPC) constitutes approximately one-third of all
pancreatic cancer, with standard of care inconsistently defined and achieving modest …

Electroporation is a bioelectric phenomenon used to deliver target molecules into cells in
vitro and irreversible electroporation (IRE) is an emerging cancer therapy used to treat …

The relationships between burst number, reversible, irreversible, and calcium
electroporation have not been comprehensively evaluated in tumor tissue-mimics. Our …

• Germline testing is now recommended for all patients with pancreatic ductal
adenocarcinoma.• In suitable patients, modified FOLFIRINOX is the adjuvant chemotherapy …