Macrophage polarization and metabolism in atherosclerosis

P Hou, J Fang, Z Liu, Y Shi, M Agostini… - Cell Death & …, 2023 - nature.com
Atherosclerosis is a chronic inflammatory disease characterized by the accumulation of fatty
deposits in the inner walls of vessels. These plaques restrict blood flow and lead to …

Six shades of vascular smooth muscle cells illuminated by KLF4 (Krüppel-Like Factor 4)

C Yap, A Mieremet, CJM de Vries, D Micha… - … , and vascular biology, 2021 - Am Heart Assoc
Multiple layers of vascular smooth muscle cells (vSMCs) are present in blood vessels
forming the media of the vessel wall. vSMCs provide a vessel wall structure, enabling it to …

Foam cells in atherosclerosis: novel insights into its origins, consequences, and molecular mechanisms

Y Gui, H Zheng, RY Cao - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …

Incomplete response to Anti-VEGF therapy in neovascular AMD: Exploring disease mechanisms and therapeutic opportunities

PS Mettu, MJ Allingham, SW Cousins - Progress in retinal and eye …, 2021 - Elsevier
Intravitreal anti-vascular endothelial growth factor (VEGF) drugs have revolutionized the
treatment of neovascular age-related macular degeneration (NVAMD). However, many …

Verification of ferroptosis and pyroptosis and identification of PTGS2 as the hub gene in human coronary artery atherosclerosis

Y Zhou, H Zhou, L Hua, C Hou, Q Jia, J Chen… - Free Radical Biology …, 2021 - Elsevier
Ferroptosis and pyroptosis have not been fully studied in atherosclerosis. We aimed to
investigate the expression of ferroptosis-related and pyroptosis-related proteins in human …

Atherosclerotic plaque healing

R Vergallo, F Crea - New England journal of medicine, 2020 - Mass Medical Soc
Atherosclerotic Plaque Healing Atherosclerotic plaque rupture and erosion result in acute
coronary syndromes. Plaque healing after initial disruption has been less extensively …

Macrophage plasticity and atherosclerosis therapy

P Lin, HH Ji, YJ Li, SD Guo - Frontiers in molecular biosciences, 2021 - frontiersin.org
Atherosclerosis is a chronic disease starting with the entry of monocytes into the
subendothelium and the subsequent differentiation into macrophages. Macrophages are the …

Macrophage polarization in atherosclerosis

S Eshghjoo, DM Kim, A Jayaraman, Y Sun, RC Alaniz - Genes, 2022 - mdpi.com
The implication of the heterogeneous spectrum of pro-and anti-inflammatory macrophages
(Macs) has been an important area of investigation over the last decade. The polarization of …

The role of macrophages in the pathogenesis of atherosclerosis

AV Blagov, AM Markin, AI Bogatyreva, TV Tolstik… - Cells, 2023 - mdpi.com
A wide variety of cell populations, including both immune and endothelial cells, participate in
the pathogenesis of atherosclerosis. Among these groups, macrophages deserve special …

More than just a monolayer: the multifaceted role of endothelial cells in the pathophysiology of atherosclerosis

M Mussbacher, K Schossleitner… - Current atherosclerosis …, 2022 - Springer
Abstract Purpose of the Review In this review, we summarize current insights into the
versatile roles of endothelial cells in atherogenesis. Recent Findings The vascular …