Human cytomegalovirus (HCMV) is a major pathogen in immunocompromised patients. The
UL146 gene exists as 14 diverse genotypes among clinical isolates, which encode 14 …

Cytomegaloviruses (CMVs) are highly adapted to their host species resulting in strict
species specificity. Hence, in vivo examination of all aspects of CMV biology employs animal …

The mechanisms underlying virus emergence are rarely well understood, making the
appearance of outbreaks largely unpredictable. This is particularly true for pathogens with …

Background Short read sequencing has been used extensively to decipher the genome
diversity of human cytomegalovirus (HCMV) strains, but falls short to reveal individual …

Human cytomegalovirus (CMV) is a major cause of morbidity in fetuses following intrauterine
infection. The glycoprotein (g) envelope trimeric gH/gL/gO and pentameric gH/gL/pUL128 …

Herpesviruses are ubiquitous, genetically diverse DNA viruses, with long-term presence in
humans associated with infrequent but significant pathology. Human leukocyte antigen …

Viruses use diverse strategies to elude the immune system, including copying and
repurposing host cytokine and cytokine receptor genes. For herpesviruses, the chemokine …

It is widely held that clinical isolates of human cytomegalovirus (HCMV) are highly cell
associated, and mutations affecting the UL128-131 and RL13 loci that arise in culture lead …

A previous phylogenetic analysis based on 32 full-length sequences of herpes simplex virus
type 1 (HSV-1) suggested three major phylogenetic groups (phylogroups) with distinct …

Background Mpox, caused by monkeypox virus (MPXV), was considered a rare zoonotic
disease before May 2022, when a global epidemic of cases in non-endemic countries led to …