[HTML][HTML] Complement activation in COVID-19 and targeted therapeutic options: a scoping review

EHT Lim, RBE van Amstel, VV de Boer, LA van Vught… - Blood Reviews, 2023 - Elsevier
Increasing evidence suggests that activation of the complement system plays a key role in
the pathogenesis and disease severity of Coronavirus disease 2019 (COVID-19). We used a …

SARS-CoV-2 immunity in animal models

Z Chen, Y Yuan, Q Hu, A Zhu, F Chen, S Li… - Cellular & molecular …, 2024 - nature.com
The COVID-19 pandemic, which was caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has become a worldwide health crisis due to its …

Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine

MS Gebre, S Rauch, N Roth, J Yu, A Chandrashekar… - Nature, 2022 - nature.com
Abstract The CVnCoV (CureVac) mRNA vaccine for severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2) was recently evaluated in a phase 2b/3 efficacy trial in …

The T-cell-directed vaccine BNT162b4 encoding conserved non-spike antigens protects animals from severe SARS-CoV-2 infection

CM Arieta, YJ Xie, DA Rothenberg, H Diao, D Harjanto… - Cell, 2023 - cell.com
T cell responses play an important role in protection against beta-coronavirus infections,
including SARS-CoV-2, where they associate with decreased COVID-19 disease severity …

N‐Acetylcysteine and Other Sulfur‐Donors as a Preventative and Adjunct Therapy for COVID‐19

HN du Preez, C Aldous, HG Kruger… - Advances in …, 2022 - Wiley Online Library
The airway epithelial glycocalyx plays an important role in preventing severe acute
respiratory syndrome coronavirus 2 entry into the epithelial cells, while the endothelial …

Guidelines for visualization and analysis of DC in tissues using multiparameter fluorescence microscopy imaging methods

F Bayerl, DA Bejarano, G Bertacchi… - European Journal of …, 2023 - Wiley Online Library
This article is part of the Dendritic Cell Guidelines article series, which provides a collection
of state‐of‐the‐art protocols for the preparation, phenotype analysis by flow cytometry …

[HTML][HTML] Complement and COVID-19: Three years on, what we know, what we don't know, and what we ought to know

WM Zelek, RA Harrison - Immunobiology, 2023 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus was identified in
China in 2019 as the causative agent of COVID-19, and quickly spread throughout the …

The immune response as a double‐edged sword: The lesson learnt during the COVID‐19 pandemic

C Agrati, R Carsetti, V Bordoni, A Sacchi… - …, 2022 - Wiley Online Library
The COVID‐19 pandemic has represented an unprecedented challenge for the humanity,
and scientists around the world provided a huge effort to elucidate critical aspects in the fight …

Persistence of immune responses to the Sinopharm/BBIBP‐CorV vaccine

C Jeewandara, IS Aberathna… - Immunity …, 2022 - Wiley Online Library
Background To determine the kinetics and persistence of immune responses following the
Sinopharm/BBIBP‐CorV, we investigated immune responses in a cohort of Sri Lankan …

Low anti‐SARS‐CoV‐2 S antibody levels predict increased mortality and dissemination of viral components in the blood of critical COVID‐19 patients

M Martin‐Vicente, R Almansa, I Martínez… - Journal of internal …, 2022 - Wiley Online Library
Abstract Background Anti‐SARS‐CoV‐2 S antibodies prevent viral replication. Critically ill
COVID‐19 patients show viral material in plasma, associated with a dysregulated host …