The Role of IL-6 in Neurodegenerative Disorders

C Shan, C Zhang, C Zhang - Neurochemical Research, 2024 - Springer
Abstract “Neurodegenerative disorder” is an umbrella term for a group of fatal progressive
neurological illnesses characterized by neuronal loss and inflammation. Interleukin-6 (IL-6) …

Neuroprotective effects of riluzole in Alzheimer's disease: A comprehensive review

M Golmohammadi, M Mahmoudian… - Fundamental & …, 2024 - Wiley Online Library
Background Despite several hundred clinical trials of drugs that initially showed promise,
there has been limited clinical improvement in Alzheimer's disease (AD). This may be …

[HTML][HTML] Novel diagnostic biomarkers of oxidative stress, immunological characterization and experimental validation in Alzheimer's disease

D Hu, X Mo, L Jihang, C Huang, H Xie, L Jin - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is a neurodegenerative condition causing cognitive decline.
Oxidative stress (OS) is believed to contribute to neuronal death and dysfunction in AD. We …

The Potential Neuroprotective Effect of Thymoquinone on Scopolamine-Induced In Vivo Alzheimer's Disease-like Condition: Mechanistic Insights

HE Abo Mansour, AI Elberri, MES Ghoneim… - Molecules, 2023 - mdpi.com
Background: Alzheimer's disease (AD) is a common neurodegenerative disorder without
effective treatment. Thymoquinone (TQ) has demonstrated potential in exhibiting anti …

Synthesis, structure revision, and anti-inflammatory activity investigation of putative blumeatin

K Xia, WJ Qi, XQ Wu, YY Song, JJ Zhu, Y Ai, Z Cui… - ACS …, 2023 - ACS Publications
Blumeatin, reported herein, bearing two hydroxyl groups at C3′ and C5′ of ring B, is
isolated from the traditional Chinese medicine Blumea balsamifera. But the isolation …

In Vitro Anti-Inflammatory Activity of Methyl Derivatives of Flavanone

M Kłósek, A Krawczyk-Łebek, E Kostrzewa-Susłow… - Molecules, 2023 - mdpi.com
Inflammation plays an important role in the immune defense against injury and infection
agents. However, the inflammatory chronic process may lead to neurodegenerative …

Erucic acid ameliorates the lipopolysaccharide‐induced memory deficit in rats through inhibited inflammation cytokines expression/caspase 3/NF‐κB pathways

N Sayyed, A Hafeez, FA Al‐Abbasi… - European Journal of …, 2023 - Wiley Online Library
Erucic acid is a single unsaturated fatty acid that falls under the omega‐9 fatty acid family. It
was suggested to treat Wistar rats with lipopolysaccharide (LPS)‐induced memory …

Repositioning of baricitinib for management of memory impairment in ovariectomized/D-galactose treated rats: A potential role of JAK2/STAT3-PI3K/AKT/mTOR …

MO Hindam, LA Ahmed, NSEL Sayed, M Khattab… - Life Sciences, 2024 - Elsevier
Aims Neuroinflammation plays a pivotal role in amyloid β (Aβ) plaques formation which is
among the hallmarks of Alzheimer's disease (AD). The present study investigated the …

Chemical Composition and Biological Activities of the Essential Oil from Citrus reticulata Blanco Peels Collected from Agrowastes

JT Job, NU Visakh, B Pathrose, A Alfarhan… - Chemistry & …, 2024 - Wiley Online Library
Citrus fruits have a thick outer coat which is often discarded due to its low economic value
and usually contributes to the waste. So this work focused on exploring the potential …

Amelioration of walnut, peony seed and camellia seed oils against d-galactose-induced cognitive impairment in mice by regulating gut microbiota

T Kang, J Zheng, C Jiang, L Jin, C Li, B Chen… - Food & Function, 2024 - pubs.rsc.org
Diet adjustment will affect the health of gut microbiota, which in turn influences the
development and function of the organism's brain through the gut–brain axis. Walnut oil …