Virus-specific CD8+ T cells that differentiate in the context of resolved versus persisting
infections exhibit divergent phenotypic and functional characteristics, which suggests that …

Abstract Interferon‐γ (IFN‐γ) is crucial for immunity against intracellular pathogens and for
tumor control. However, aberrant IFN‐γ expression has been associated with a number of …

T‐cell exhaustion is characterized by the stepwise and progressive loss of T‐cell functions
and can culminate in the physical deletion of the responding cells. Exhaustion is well …

T cells mediate effector functions through a variety of mechanisms. Recently, multiparameter
flow cytometry has allowed a simultaneous assessment of the phenotype and multiple …

An important question in memory development is understanding the differences between
effector CD8 T cells that die versus effector cells that survive and give rise to memory cells …

Natural killer (NK) cells are lymphocytes of the innate immune system that, following
differentiation from CD56bright to CD56dim cells, have been thought to retain fixed …

The ability to develop and sustain populations of memory T cells after infection or
immunization is a hallmark of the adaptive immune response and a basis for protective …

A diverse T cell repertoire is essential for a vigorous immune response to new infections,
and decreasing repertoire diversity has been implicated in the age-associated decline in …

Blunting autoreactivity without compromising immunity remains an elusive goal in the
treatment of autoimmunity. We show that progression to autoimmune diabetes results in the …

The live yellow fever vaccine (YF-17D) offers a unique opportunity to study memory CD8+ T
cell differentiation in humans following an acute viral infection. We have performed a …