Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission

ROM Rego, JJA Trentelman, J Anguita, AM Nijhof… - Parasites & vectors, 2019 - Springer
Hematophagous arthropods are responsible for the transmission of a variety of pathogens
that cause disease in humans and animals. Ticks of the Ixodes ricinus complex are vectors …

African swine fever virus interaction with host innate immune factors

AE Afe, ZJ Shen, X Guo, R Zhou, K Li - Viruses, 2023 - mdpi.com
African swine fever virus (ASFV) adversely affects pig farming owing to its 100% mortality
rate. The condition is marked by elevated body temperature, bleeding, and ataxia in …

Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins

SR Devkota, P Aryal, R Pokhrel, W Jiao, A Perry… - Nature …, 2023 - nature.com
Chemokines are key regulators of leukocyte trafficking and attractive targets for anti-
inflammatory therapy. Evasins are chemokine-binding proteins from tick saliva, whose …

Acaricides resistance in ticks: selection, diagnosis, mechanisms, and mitigation

MK Obaid, N Islam, A Alouffi, AZ Khan… - Frontiers in Cellular …, 2022 - frontiersin.org
Ticks are blood-feeding ecto-parasites that have a cosmopolitan distribution in tropical and
subtropical regions of the world. Ticks cause economic losses in the form of reduced blood …

Tick salivary kunitz-type inhibitors: targeting host hemostasis and immunity to mediate successful blood feeding

MA Jmel, H Voet, RN Araújo, L Tirloni… - International Journal of …, 2023 - mdpi.com
Kunitz domain-containing proteins are ubiquitous serine protease inhibitors with promising
therapeutic potential. They target key proteases involved in major cellular processes such as …

Expounding the role of tick in Africa swine fever virus transmission and seeking effective prevention measures: A review

T Lv, X Xie, N Song, S Zhang, Y Ding, K Liu… - Frontiers in …, 2022 - frontiersin.org
African swine fever (ASF), a highly contagious, deadly infectious disease, has caused huge
economic losses to animal husbandry with a 100% mortality rate of the most acute and acute …

First report on detection of Hepatozoon ayorgbor in Rhipicephalus haemaphysaloides and Hepatozoon colubri in Haemaphysalis sulcata and Hyalomma anatolicum: risks of …

H Tila, M Khan, MM Almutairi, A Alouffi… - Frontiers in Veterinary …, 2023 - frontiersin.org
This study aimed to detect Hepatozoon spp. in ticks infesting asymptomatic domestic
animals and to provide insight into their potential spillover from wild to domestic animals. In …

Cross-species immunoprotective antigens (subolesin, ferritin 2 and P0) provide protection against Rhipicephalus sanguineus sensu lato

I Zeb, LF Parizi, M Israr, I da Silva Vaz Jr, A Ali - Parasites & Vectors, 2024 - Springer
Background Tick control is mostly hampered by the rise of acaricide-resistant tick
populations. Significant efforts have focused on developing alternative control methods …

Universal tick vaccines: candidates and remaining challenges

LF Parizi, NW Githaka, C Logullo, J Zhou, M Onuma… - Animals, 2023 - mdpi.com
Simple Summary Various new technologies have been used to learn more about tick
physiology and biology in hopes of developing vaccines to protect people and animals from …

A multiepitope chimeric antigen from Rhipicephalus microplus-secreted salivary proteins elicits anti-tick protective antibodies in rabbit

GCA Costa, FAA Silva, VM Manzato, RJS Torquato… - Veterinary …, 2023 - Elsevier
Abstract Rhipicephalus (Boophilus) microplus, the Cattle Fever Tick, causes significant
economic losses in livestock in tropical and subtropical regions of the world. As the usual …