We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

The hippocampal formation has been implicated in a growing number of disorders, from
Alzheimer's disease and cognitive ageing to schizophrenia and depression. How can the …

Background: Depression is the most debilitating neuropsychiatric disorder with significant
impact on socio-occupational and well being of individual. The exact pathophysiology of …

Highlights•Diverse animal models of depression and anxiety have impaired neurogenesis.•
Neurogenesis is consistently boosted by antidepressants in animal models when animals …

Clinical and preclinical studies have demonstrated that depression, one of the most common
psychiatric illnesses, is associated with reduced levels of neurotrophic factors, including …

Abstract N, N-dimethyltryptamine (DMT) is a component of the ayahuasca brew traditionally
used for ritual and therapeutic purposes across several South American countries. Here, we …

The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated
calcium channels. Initially licensed for pain and seizures, they have become widely …

Depressed individuals typically show poor memory for positive events, potentiated memory
for negative events, and impaired recollection. These phenomena are clinically important …

There is evidence that excessive stress exposure of the brain, mediated through the
neurotoxic effects of cortisol and possibly neuroinflammation, causes damage to brain …

Background Hippocampal volume loss is a hallmark of clinical depression. Chronic stress
produces volume loss in the hippocampus in humans and atrophy of CA3 pyramidal cells …