Diabetic kidney disease (DKD) occurs in∼ 40% of patients with diabetes and causes kidney
failure, cardiovascular disease, and premature death. We analyzed the response of a …

Neurons in the cerebral cortex connect through descending pathways to hindbrain and
spinal cord to activate muscle and generate movement. Although components of this …

Schizophrenia is a psychiatric disorder whose pathophysiology is largely unknown. It has a
heritability of 60-80%, much of which is attributable to common risk alleles, suggesting …

We used the 10x Genomics Visium platform to define the spatial topography of gene
expression in the six-layered human dorsolateral prefrontal cortex. We identified extensive …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

Understanding spinal cord assembly is essential to elucidate how motor behavior is
controlled and how disorders arise. The human spinal cord is exquisitely organized, and this …

INTRODUCTION Our understanding of the pathophysiology of psychiatric disorders,
including autism spectrum disorder (ASD), schizophrenia (SCZ), and bipolar disorder (BD) …

The mammalian nervous system executes complex behaviors controlled by specialized,
precisely positioned, and interacting cell types. Here, we used RNA sequencing of half a …

Single-nucleus RNA sequencing (snRNA-seq) is used as an alternative to single-cell RNA-
seq, as it allows transcriptomic profiling of frozen tissue. However, it is unclear whether …

We describe a human single-nuclei transcriptomic atlas for the substantia nigra (SN),
generated by sequencing approximately 17,000 nuclei from matched cortical and SN …