Single-cell gene expression technologies are powerful tools to study cell types in the human
brain, but efforts have largely focused on cortical brain regions. We therefore created a …

Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral
small vessel disease (SVD), hypertension being the main known risk factor. Here, we …

A common belief among statistical geneticists is that genomewide association studies
1(GWAS) rendered candidate gene studies 2 obsolete. It is also widely believed that nearly …

The cellular neurobiology of schizophrenia remains poorly understood. We discuss
neuroimaging studies, pathological findings, and experimental work supporting the idea that …

Genome-wide association studies have discovered hundreds of loci associated with
complex brain disorders, but it remains unclear in which cell types these loci are active. Here …

Schizophrenia has a heritability of 60-80% 1, much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

Major depressive disorder emerges from the complex interactions of biological systems that
span genes and molecules through cells, networks, and behavior. Establishing how …

Most studies of gene expression in the brains of individuals with schizophrenia have
focused on cortical regions, but subcortical nuclei such as the striatum are prominently …

Polygenic risk scores (PRSs) have been among the leading advances in biomedicine in
recent years. As a proxy of genetic liability, PRSs are utilised across multiple fields and …