Despite the strong genetic basis of psychiatric disorders, the underlying molecular
mechanisms are largely unmapped. RNA-binding proteins (RBPs) are responsible for most …

The power of human induced pluripotent stem cell (hiPSC)-based studies to resolve the
smaller effects of common variants within the size of cohorts that can be realistically …

Genome-wide association studies (GWASs) have identified over 180 independent
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …

The function of the mammalian brain relies upon the specification and spatial positioning of
diversely specialized cell types. Yet, the molecular identities of the cell types, and their …

Large-scale genomic studies of schizophrenia have identified hundreds of genetic loci
conferring risk to the disorder. This progress offers an important route toward defining the …

Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …

Viral genetic tools that target specific brain cell types could transform basic neuroscience
and targeted gene therapy. Here, we use comparative open chromatin analysis to identify …

Genome-wide association studies (GWAS) have mapped thousands of susceptibility loci
associated with immune-mediated diseases. To assess the extent of the genetic sharing …

The chromatin landscape of human brain cells encompasses key information to
understanding brain function. Here we use ATAC-seq to profile the chromatin structure in …

Background Schizophrenia is a severe mental illness afflicting young adults just as they
approach their full potential, often resulting in a lifetime of severe disability. While many …