FLT3 inhibitors and novel therapeutic strategies to reverse AML resistance: An updated comprehensive review
FMS-like tyrosine kinase 3 (FLT3) mutations occur in almost 30% of acute myeloid leukemia
(AML) patients. Despite the initial clinical efficacy of FLT3 inhibitors, many treated AML …
(AML) patients. Despite the initial clinical efficacy of FLT3 inhibitors, many treated AML …
FLT3-targeted treatment for acute myeloid leukemia
Y Arai, SG Chi, Y Minami, M Yanada - International journal of hematology, 2022 - Springer
Mutations in the FMS-like tyrosine kinase 3 (FLT3) gene are detected in approximately 30%
of acute myeloid leukemia (AML). The high frequency of FLT3 mutations, along with their …
of acute myeloid leukemia (AML). The high frequency of FLT3 mutations, along with their …
Computational investigation to identify potent inhibitors of the GTPase-Kirsten RAt sarcoma virus (K-Ras) mutants G12C and G12D
K-Ras mutations are frequent in various cancer types, and according to recent research, K-
Ras possesses four-drug targeting sites. This increased our interest in finding potential small …
Ras possesses four-drug targeting sites. This increased our interest in finding potential small …
In silico investigation on the mutational analysis of BRCA1-BARD1 RING domains and its effect on nucleosome recognition and ubiquitination
The BRCA1-BARD1 complex is a crucial tumor suppressor E3 ubiquitin ligase involved in
DNA double-stranded break repair. The BRCA1-BARD1 RING domains interact with …
DNA double-stranded break repair. The BRCA1-BARD1 RING domains interact with …
Understanding gilteritinib resistance to FLT3-F691L mutation through an integrated computational strategy
S Zhou, B Yang, Y Xu, A Gu, J Peng, J Fu - Journal of Molecular Modeling, 2022 - Springer
FMS-like tyrosine kinase 3 (FLT3) serves as an important drug target for acute myeloid
leukemia (AML), and gene mutations of FLT3 have been closely associated with AML …
leukemia (AML), and gene mutations of FLT3 have been closely associated with AML …
How ITD Insertion Sites Orchestrate the Biology and Disease of FLT3-ITD-Mutated Acute Myeloid Leukemia
TR Haage, B Schraven, D Mougiakakos, T Fischer - Cancers, 2023 - mdpi.com
Simple Summary FLT3 gene mutations are among the most common genetic aberrations
detected in AML and occur with a frequency of approximately 30%, mainly as internal …
detected in AML and occur with a frequency of approximately 30%, mainly as internal …
Mechanistic Insights into the Binding of Boar Salivary Pheromones and Putative Molecule with Receptor Proteins: A Comparative Computational Approach
D Sankarganesh, A Balasundaram, GP Doss C… - ACS …, 2024 - ACS Publications
Precise estrus detection in sows is pivotal in increasing the productivity within the pork
industry. Sows in estrus exhibit exclusive behaviors when exposed to either a live boar or …
industry. Sows in estrus exhibit exclusive behaviors when exposed to either a live boar or …
Prediction of Cholecystokinin-Secretory Peptides Using Bidirectional Long Short-term Memory Model Based on Transfer Learning and Hierarchical Attention Network …
J Liu, P Chen, H Song, P Zhang, M Wang, Z Sun… - Biomolecules, 2023 - mdpi.com
Cholecystokinin (CCK) can make the human body feel full and has neurotrophic and anti-
inflammatory effects. It is beneficial in treating obesity, Parkinson's disease, pancreatic …
inflammatory effects. It is beneficial in treating obesity, Parkinson's disease, pancreatic …
Copper-mediated cyclization of thiosemicarbazones leading to 1, 3, 4-thiadiazoles: Structural elucidation, DFT calculations, in vitro biological evaluation and in silico …
V Manakkadan, J Haribabu… - … Acta Part A: Molecular …, 2024 - Elsevier
Cancer's global impact necessitates innovative and less toxic treatments.
Thiosemicarbazones (TSCs), adaptable metal chelators, offer such potential. In this study …
Thiosemicarbazones (TSCs), adaptable metal chelators, offer such potential. In this study …
Molecular interaction of a putative inhibitor with bacterial SHV, an enzyme associated with antibiotic resistance
S Shakil, SM Danish Rizvi… - Royal Society Open …, 2023 - royalsocietypublishing.org
Tackling the ever-looming threat of antibiotic resistance remains a challenge for clinicians
and microbiologists across the globe. Sulfhydryl variable (SHV) is a known bacterial enzyme …
and microbiologists across the globe. Sulfhydryl variable (SHV) is a known bacterial enzyme …