Eosinophils have been considered end-stage cells involved in host protection against
parasites. However, numerous lines of evidence have now changed this perspective by …

Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of diverse inflammatory responses, as well as modulators of innate and adaptive immunity …

Abstract THE IDIOPATHIC hypereosinophilic syndrome (HES) is a leukoproliferative
disorder, or more likely disorders, marked by a sustained overproduction of eosinophils. The …

IL-5 was originally defined as a T-cell-derived cytokine that triggers activated B cells for
terminal differentiation into antibody-secreting plasma cells, at least in mice. Concurrently, IL …

Whether B-1a (CD5+) cells are a distinct lineage derived from committed fetal/neonatal
precursors or arise from follicular B-2 cells in response to BCR ligation and other, unknown …

IL-5 is involved in a number of immune responses such as helminth infection and allergy. IL-
5 also plays roles in innate immunity by maintaining B-1 B cells and mucosal IgA production …

Natural antibodies are produced at tightly regulated levels in the complete absence of
external antigenic stimulation. They provide immediate, early and broad protection against …

In this review, we aim to put in perspective the biology of a multifunctional leukocyte, the
eosinophil, by placing it in the context of innate and adaptive immune responses …

Mice deficient in interleukin-5 (IL-5−/− mice) were generated by gene targeting in embryonal
stem cells. Contrary to previous studies, no obligatory role for IL-5 was demonstrated in the …

The imbalance between osteogenesis and osteoclastogenesis is a feature of bone
metabolic disease. Cadmium (Cd) exposure causes human bone loss and osteoporosis …