[HTML][HTML] A compendium of genetic regulatory effects across pig tissues
Abstract The Farm Animal Genotype-Tissue Expression (FarmGTEx) project has been
established to develop a public resource of genetic regulatory variants in livestock, which is …
established to develop a public resource of genetic regulatory variants in livestock, which is …
[HTML][HTML] Identification of constrained sequence elements across 239 primate genomes
Noncoding DNA is central to our understanding of human gene regulation and complex
diseases,, and measuring the evolutionary sequence constraint can establish the functional …
diseases,, and measuring the evolutionary sequence constraint can establish the functional …
[HTML][HTML] Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying human complex traits and diseases
Genome-wide association studies (GWAS) of human complex traits or diseases often
implicate genetic loci that span hundreds or thousands of genetic variants, many of which …
implicate genetic loci that span hundreds or thousands of genetic variants, many of which …
[HTML][HTML] Nuclear genetic control of mtDNA copy number and heteroplasmy in humans
Mitochondrial DNA (mtDNA) is a maternally inherited, high-copy-number genome required
for oxidative phosphorylation. Heteroplasmy refers to the presence of a mixture of mtDNA …
for oxidative phosphorylation. Heteroplasmy refers to the presence of a mixture of mtDNA …
A Bayesian fine-mapping model using a continuous global-local shrinkage prior with applications in prostate cancer analysis
The aim of fine mapping is to identify genetic variants causally contributing to complex traits
or diseases. Existing fine-mapping methods employ Bayesian discrete mixture priors and …
or diseases. Existing fine-mapping methods employ Bayesian discrete mixture priors and …
[HTML][HTML] XMAP: Cross-population fine-mapping by leveraging genetic diversity and accounting for confounding bias
Fine-mapping prioritizes risk variants identified by genome-wide association studies
(GWASs), serving as a critical step to uncover biological mechanisms underlying complex …
(GWASs), serving as a critical step to uncover biological mechanisms underlying complex …
MultiSuSiE improves multi-ancestry fine-mapping in All of Us whole-genome sequencing data
Leveraging data from multiple ancestries can greatly improve fine-mapping power due to
differences in linkage disequilibrium and allele frequencies. We propose MultiSuSiE, an …
differences in linkage disequilibrium and allele frequencies. We propose MultiSuSiE, an …
[HTML][HTML] Fine-mapping causal tissues and genes at disease-associated loci
Heritable diseases often manifest in a highly tissue-specific manner, with different disease
loci mediated by genes in distinct tissues or cell types. We propose Tissue-Gene Fine …
loci mediated by genes in distinct tissues or cell types. We propose Tissue-Gene Fine …
A novel bayesian fine-mapping model using a continuous global-local shrinkage prior with applications in prostate cancer analysis
The aim of fine-mapping is to identify genetic variants causally contributing to complex traits
or diseases. Existing fine-mapping methods employ discrete Bayesian mixture priors and …
or diseases. Existing fine-mapping methods employ discrete Bayesian mixture priors and …
Genetic fine-mapping from summary data using a nonlocal prior improves the detection of multiple causal variants
V Karhunen, I Launonen, MR Järvelin, S Sebert… - …, 2023 - academic.oup.com
Motivation Genome-wide association studies (GWAS) have been successful in identifying
genomic loci associated with complex traits. Genetic fine-mapping aims to detect …
genomic loci associated with complex traits. Genetic fine-mapping aims to detect …