Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to
produce the levels of ATP required to perform physiological functions exceeds the vascular …

Acute kidney injury (AKI) is a global public health concern associated with high morbidity
and mortality. Although advances in medical management have improved the in-hospital …

Acute kidney injury (AKI), commonly caused by ischemia, sepsis, or nephrotoxic insult, is
associated with increased mortality and a heightened risk of chronic kidney disease (CKD) …

Overwhelming lipid peroxidation induces ferroptotic stress and ferroptosis, a non-apoptotic
form of regulated cell death that has been implicated in maladaptive renal repair in mice and …

Kidney tubular epithelial cells (TECs) have a crucial role in the damage and repair response
to acute and chronic injury. To adequately respond to constant changes in the environment …

Glucose levels are tightly regulated at all times. Gluconeogenesis is the metabolic pathway
dedicated to glucose synthesis from non-hexose precursors. Gluconeogenesis is critical for …

Metabolic reprogramming to glycolysis is closely associated with the development of chronic
kidney disease (CKD). Although it has been reported that phosphofructokinase 1 (PFK) is a …

The steps governing healing with or without fibrosis within the same microenvironment are
unclear. After acute kidney injury (AKI), injured proximal tubular epithelial cells activate …

Background and aims Nephrolithiasis is a common renal disease with no effective
medication. Sodium-glucose cotransporter-2 (SGLT2) inhibitors, an anti-diabetic agent, have …

The kidney proximal tubule is a key organ for human metabolism. The kidney responds to
stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate …