Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in
longevity and age‐related metabolic dysfunction. Fat distribution and function change …

Activation of the KEAP1-NRF2 signaling pathway is an adaptive response to environmental
and endogenous stresses and serves to render animals resistant to chemical …

Background There is compelling evidence associating senescent cells with the malignant
progression of tumours. Of all senescence-related mechanisms, the so-called senescence …

Background—Aging and aging-related disorders impair the survival and differentiation
potential of bone marrow mesenchymal stem cells (MSCs) and limit their therapeutic …

Inflammatory mediators have the potential to impact a surprising range of diseases,
including obesity and its associated metabolic syndrome. In this paper, we show that the …

Attainment of a brown adipocyte cell phenotype in white adipocytes, with their abundant
mitochondria and increased energy expenditure potential, is a legitimate strategy for …

The metabolic syndrome is associated with a dysregulated adipose tissue; in part a
consequence of adipose cell enlargement and the associated infiltration of macrophages …

We report a chemically defined, efficient, scalable and reproducible protocol for
differentiation of human embryonic stem cells (hESCs) toward chondrocytes. HESCs are …

Obesity is a condition associated with the accumulation of excess fat in the body, energy
imbalance, lipogenesis, etc., which increases adipose tissue mass through adipogenesis …

Transforming growth factor‐beta (TGF‐β) is an important growth inhibitor of epithelial cells,
and insensitivity to this cytokine results in uncontrolled cell proliferation and can contribute to …