[HTML][HTML] LncRNA Rik-203 contributes to anesthesia neurotoxicity via microRNA-101a-3p and GSK-3β-mediated neural differentiation

L Zhang, J Yan, Q Liu, Z Xie, H Jiang - Scientific reports, 2019 - nature.com
The mechanism of anesthesia neurotoxicity remains largely to be determined. The effects of
long noncoding RNAs (LncRNAs) on neural differentiation and the underlying mechanisms …

[HTML][HTML] Prophylactic progesterone prevents adverse behavioural and neurocognitive effects of neonatal anaesthesia exposure in rat

B Wali, I Sayeed, DG Stein, J Raper - British Journal of Anaesthesia, 2022 - Elsevier
Background Evidence from animal models and human studies suggests an association
between early general anaesthesia exposure and development of long-lasting …

[HTML][HTML] Long non-coding RNA Peg13 attenuates the sevoflurane toxicity against neural stem cells by sponging microRNA-128-3p to preserve Sox13 expression

Y Jiang, Y Wang, Y Sun, H Jiang - PLoS One, 2020 - journals.plos.org
Background Exposure to anesthetics during brain development may impair neurological
function, however, the mechanisms underlying anesthetic neurotoxicity are unclear. Recent …

Isoflurane is more deleterious to developing brain than desflurane: the role of the Akt/GSK3β signaling pathway

G Tao, Q Xue, Y Luo, G Li, Y Xia… - BioMed research …, 2016 - Wiley Online Library
Demand is increasing for safer inhalational anesthetics for use in pediatric anesthesia. In
this regard, researchers have debated whether isoflurane is more toxic to the developing …

[HTML][HTML] Isoflurane and sevoflurane induce cognitive impairment in neonatal rats by inhibiting neural stem cell development through microglial activation …

C Zuo, J Ma, Y Pan, D Zheng, C Chen, N Ruan… - Neurotoxicity …, 2022 - Springer
Inhaled anesthetics are known to induce neurotoxicity in the developing brains of rodents,
although the mechanisms are not well understood. The aim of this study was to elucidate the …

Glycyrrhizin attenuates isoflurane-induced cognitive deficits in neonatal rats via its anti-inflammatory activity

W Wang, X Chen, J Zhang, Y Zhao, S Li, L Tan, J Gao… - Neuroscience, 2016 - Elsevier
Children exposed to general anesthetics such as isoflurane are maybe at an increased risk
of cognitive impairment. Recent studies have indicated that this kind of cognitive decline is …

[HTML][HTML] Application of nonhuman primate models in the studies of pediatric anesthesia neurotoxicity

C Wang, S Liu, F Liu, A Bhutta, TA Patterson… - Anesthesia & …, 2022 - journals.lww.com
Numerous animal models have been used to study developmental neurotoxicity associated
with short-term or prolonged exposure of common general anesthetics at clinically relevant …

Anesthetic neurotoxicity in the newborn and infant

EA Olsen, AM Brambrink - Current Opinion in Anesthesiology, 2013 - journals.lww.com
Anesthetic neurotoxicity in the newborn and infant : Current Opinion in Anesthesiology
Anesthetic neurotoxicity in the newborn and infant : Current Opinion in Anesthesiology Log in or …

Electroacupuncture alleviates postoperative cognitive dysfunction in aged rats by inhibiting hippocampal neuroinflammation activated via microglia/TLRs pathway

P Feng, P Deng, L Liu, Q Ai, J Yin… - Evidence‐Based …, 2017 - Wiley Online Library
Neuroinflammation has been suggested to be involved in the pathogenesis of postoperative
cognitive dysfunction (POCD). Electroacupuncture (EA) is an irreplaceable method in …

Impact of anesthesia exposure in early development on learning and sensory functions

DP Aksenov, MJ Miller, CJ Dixon… - Developmental …, 2020 - Wiley Online Library
Each year, millions of children undergo anesthesia, and both human and animal studies
have indicated that exposure to anesthesia at an early age can lead to neuronal damage …