Genetic insights into the neurodevelopmental origins of schizophrenia
R Birnbaum, DR Weinberger - Nature Reviews Neuroscience, 2017 - nature.com
Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …
neurobiological investigation. Although the underlying causal mechanisms remain …
Translating genome-wide association findings into new therapeutics for psychiatry
Genome-wide association studies (GWAS) in psychiatry, once they reach sufficient sample
size and power, have been enormously successful. The Psychiatric Genomics Consortium …
size and power, have been enormously successful. The Psychiatric Genomics Consortium …
Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases
Identification of therapeutic targets from genome-wide association studies (GWAS) requires
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing …
Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk
KA Perzel Mandell, NJ Eagles, R Wilton… - Nature …, 2021 - nature.com
DNA methylation (DNAm) is an epigenetic regulator of gene expression and a hallmark of
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
gene-environment interaction. Using whole-genome bisulfite sequencing, we have surveyed …
Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits
Cigarette smoking is the leading cause of preventable morbidity and mortality. Genetic
variation contributes to initiation, regular smoking, nicotine dependence, and cessation. We …
variation contributes to initiation, regular smoking, nicotine dependence, and cessation. We …
Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk
Specific cell populations may have unique contributions to schizophrenia but may be missed
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …
Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model
Estimating the polygenicity (proportion of causally associated single nucleotide
polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human …
polymorphisms (SNPs)) and discoverability (effect size variance) of causal SNPs for human …
[PDF][PDF] Whole-genome and RNA sequencing reveal variation and transcriptomic coordination in the developing human prefrontal cortex
Gene expression levels vary across developmental stage, cell type, and region in the brain.
Genomic variants also contribute to the variation in expression, and some neuropsychiatric …
Genomic variants also contribute to the variation in expression, and some neuropsychiatric …
Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
EE Burke, JG Chenoweth, JH Shin… - Nature …, 2020 - nature.com
Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural
differentiation and maturation. We present a hiPSC transcriptomics resource on …
differentiation and maturation. We present a hiPSC transcriptomics resource on …
Genetics and brain transcriptomics of completed suicide
Objective: The authors sought to study the transcriptomic and genomic features of completed
suicide by parsing the method chosen, to capture molecular correlates of the distinctive …
suicide by parsing the method chosen, to capture molecular correlates of the distinctive …