Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …

Background—Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone
Antagonist (TOPCAT) patients with heart failure and preserved left ventricular ejection …

Background: The diagnosis of heart failure may be challenging because symptoms are
rather nonspecific. Elevated left ventricular (LV) filling pressure may be used to confirm the …

Background: Recent trial data suggest that stratification of patients with heart failure with
preserved ejection fraction (HFpEF) according to left ventricular ejection fraction (LVEF) …

2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American
College of Cardiology Foundation/American Heart Association Task Force on Practice …

Background—Characterization of myocardial structural changes in heart failure with
preserved ejection fraction (HFpEF) has been hindered by the limited availability of human …

Macrophages populate the healthy myocardium and, depending on their phenotype, may
contribute to tissue homeostasis or disease. Their origin and role in diastolic dysfunction, a …

Background Nitrates are commonly prescribed to enhance activity tolerance in patients with
heart failure and a preserved ejection fraction. We compared the effect of isosorbide …

One in 10 persons in the world aged 40 years and older will develop the syndrome of
HFpEF (heart failure with preserved ejection fraction), the most common form of chronic …

Heart failure (HF) has been singled out as an epidemic and is a staggering clinical and
public health problem, associated with significant mortality, morbidity, and healthcare …