Background—Heart failure with preserved ejection fraction (EF) is a common syndrome, but
trends in treatments and outcomes are lacking. Methods and Results—We analyzed data …

Background: In nonrandomized, open-label studies, a transcatheter interatrial shunt device
(IASD, Corvia Medical) was associated with lower pulmonary capillary wedge pressure …

Heart failure (HF) is the quintessential cardiovascular syndrome of aging that results from
age-related cardiovascular conditions and age-associated changes in cardiovascular …

Heart failure is the leading cause of hospitalization among adults 65 years of age in the
United States. Annually, 1 million patients are hospitalized with a primary diagnosis of heart …

There is a constant high demand for energy to sustain the continuous contractile activity of
the heart, which is met primarily by the β-oxidation of long-chain fatty acids. The control of …

Abstract Background: The PARAGON-HF (Prospective Comparison of ARNI With ARB
Global Outcomes in HF With Preserved Ejection Fraction) trial tested the efficacy of sacubitril …

Objectives: The aim of this study was to evaluate the prevalence and prognostic impacts of
noncardiac comorbidities in patients with heart failure (HF) with preserved ejection fraction …

Coronary artery disease is a major underlying etiology for heart failure. The role of coronary
microvascular disease, and endothelial dysfunction, in the pathophysiology of heart failure is …

Background—Exercise capacity as measured by peak oxygen uptake (Vo2) is similarly
impaired in patients with heart failure with preserved ejection fraction (HFpEF) and heart …

Aims Right ventricular (RV) dysfunction and pulmonary hypertension (PH) are increasingly
recognized in heart failure with preserved ejection fraction (HFpEF). The prevalence and …