The roles and implications of RNA m6A modification in cancer

X Deng, Y Qing, D Horne, H Huang… - Nature Reviews Clinical …, 2023 - nature.com
Abstract N 6-Methyladenosine (m6A), the most prevalent internal modification in eukaryotic
mRNA, has been extensively and increasingly studied over the past decade. Dysregulation …

Methyltransferase-like proteins in cancer biology and potential therapeutic targeting

YN Qi, Z Liu, LL Hong, P Li, ZQ Ling - Journal of Hematology & Oncology, 2023 - Springer
RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

m6A methylation: a process reshaping the tumour immune microenvironment and regulating immune evasion

X Cao, Q Geng, D Fan, Q Wang, X Wang, M Zhang… - Molecular cancer, 2023 - Springer
Abstract N6-methyladenosine (m6A) methylation is the most universal internal modification
in eukaryotic mRNA. With elaborate functions executed by m6A writers, erasers, and …

N6-methyladenosine reader YTHDF family in biological processes: structures, roles, and mechanisms

L Chen, Y Gao, S Xu, J Yuan, M Wang, T Li… - Frontiers in …, 2023 - frontiersin.org
As the most abundant and conserved internal modification in eukaryote RNAs, N6-
methyladenosine (m6A) is involved in a wide range of physiological and pathological …

m6A-regulated tumor glycolysis: new advances in epigenetics and metabolism

SW Yue, HL Liu, HF Su, C Luo, HF Liang, BX Zhang… - Molecular Cancer, 2023 - Springer
Glycolytic reprogramming is one of the most important features of cancer and plays an
integral role in the progression of cancer. In cancer cells, changes in glucose metabolism …

Novel strategies to reverse chemoresistance in colorectal cancer

SC Ma, JQ Zhang, TH Yan, MX Miao, YM Cao… - Cancer …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is a common gastrointestinal malignancy with high morbidity and
fatality. Chemotherapy, as traditional therapy for CRC, has exerted well antitumor effect and …

[HTML][HTML] Unraveling the function of epithelial-mesenchymal transition (EMT) in colorectal cancer: Metastasis, therapy response, and revisiting molecular pathways

E Sabouni, MM Nejad, S Mojtabavi… - Biomedicine & …, 2023 - Elsevier
Colorectal cancer (CRC) is a dangerous form of cancer that affects the gastrointestinal tract.
It is a major global health concern, and the aggressive behavior of tumor cells makes it …

The roles of m6A methylation in cervical cancer: functions, molecular mechanisms, and clinical applications

Z Mao, B Wang, T Zhang, B Cui - Cell Death & Disease, 2023 - nature.com
Cervical cancer (CC) is a gynecological neoplasm with the highest incidence rate, primarily
attributed to the persistent infection of high-risk Human papillomavirus (HPV). Despite …

Disheveled3 enhanced EMT and cancer stem-like cells properties via Wnt/β-catenin/c-Myc/SOX2 pathway in colorectal cancer

Z Li, Z Yang, W Liu, W Zhu, L Yin, Z Han, Y Xian… - Journal of Translational …, 2023 - Springer
Background Epithelial-to-mesenchymal transition (EMT) and cancer stem-like cells (CSLCs)
play crucial role in tumor metastasis and drug-resistance. Disheveled3 (DVL3) is involved in …

Roles and implications of mRNA N6‐methyladenosine in cancer

L Zeng, X Huang, J Zhang, D Lin… - Cancer …, 2023 - Wiley Online Library
RNA N6‐methyladenosine modification is the most prevalent internal modification of
eukaryotic RNAs and has emerged as a novel field of RNA epigenetics, garnering increased …