Epigenetic clock: A promising biomarker and practical tool in aging
R Duan, Q Fu, Y Sun, Q Li - Ageing Research Reviews, 2022 - Elsevier
As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …
Epigenetic aging as a biomarker of dementia and related outcomes: a systematic review
Background: Biological aging may be a robust biomarker of dementia or cognitive
performance. This systematic review synthesized the evidence for an association between …
performance. This systematic review synthesized the evidence for an association between …
A computational solution for bolstering reliability of epigenetic clocks: Implications for clinical trials and longitudinal tracking
AT Higgins-Chen, KL Thrush, Y Wang, CJ Minteer… - Nature aging, 2022 - nature.com
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …
but this data can be surprisingly unreliable. Here we show that technical noise produces …
Associations of age, sex, race/ethnicity, and education with 13 epigenetic clocks in a nationally representative US sample: the Health and Retirement Study
Background Many DNA methylation-based indicators have been developed as summary
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …
[HTML][HTML] Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden
Background Individuals of the same chronological age display different rates of biological
ageing. A number of measures of biological age have been proposed which harness age …
ageing. A number of measures of biological age have been proposed which harness age …
[HTML][HTML] High social status males experience accelerated epigenetic aging in wild baboons
Aging, for virtually all life, is inescapable. However, within populations, biological aging rates
vary. Understanding sources of variation in this process is central to understanding the …
vary. Understanding sources of variation in this process is central to understanding the …
[HTML][HTML] Education and lifestyle factors are associated with DNA methylation clocks in older African Americans
DNA methylation (DNAm) clocks are important biomarkers of cellular aging and are
associated with a variety of age-related chronic diseases and all-cause mortality. Examining …
associated with a variety of age-related chronic diseases and all-cause mortality. Examining …
Assessment of epigenetic clocks as biomarkers of aging in basic and population research
ME Levine - The Journals of Gerontology: Series A, 2020 - academic.oup.com
The Geoscience paradigm suggests that targeting the aging process could delay or prevent
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …
the risk of multiple major age-related diseases, such as cancer, cardiovascular disease …
The socioeconomic gradient in epigenetic ageing clocks: evidence from the multi-ethnic study of atherosclerosis and the health and retirement study
Epigenetic clocks have been widely used to predict disease risk in multiple tissues or cells.
Their success as a measure of biological ageing has prompted research on the connection …
Their success as a measure of biological ageing has prompted research on the connection …
Epigenetic aging in older breast cancer survivors and noncancer controls: preliminary findings from the Thinking and Living with Cancer Study
Background Cancer and its treatments may accelerate aging in survivors; however, research
has not examined epigenetic markers of aging in longer term breast cancer survivors. This …
has not examined epigenetic markers of aging in longer term breast cancer survivors. This …