Fundamental role of BMP15 in human ovarian folliculogenesis revealed by null and missense mutations associated with primary ovarian insufficiency

R Rossetti, I Ferrari, I Bestetti, S Moleri… - Human …, 2020 - Wiley Online Library
Abstract Bone morphogenetic protein 15 (BMP15) encodes an oocyte factor with a relevant
role for folliculogenesis as homodimer or cumulin heterodimer (BMP15‐GDF9) …

Genome-wide scans identify known and novel regions associated with prolificacy and reproduction traits in a sub-Saharan African indigenous sheep (Ovis aries)

AT Dolebo, N Khayatzadeh, A Melesse, D Wragg… - Mammalian …, 2019 - Springer
Maximizing the number of offspring born per female is a key functionality trait in commercial-
and/or subsistence-oriented livestock enterprises. Although the number of offspring born is …

High-throughput sequencing to identify monogenic etiologies in a preselected polycystic ovary syndrome cohort

RP Crespo, TP Rocha, LR Montenegro… - Journal of the …, 2022 - academic.oup.com
Context Polycystic ovary syndrome (PCOS) etiology remains to be elucidated, but familial
clustering and twin studies have shown a strong heritable component. Objective The …

Optimizing fertility in primary ovarian insufficiency: case report and literature review

KC Piedade, H Spencer, L Persani, LM Nelson - Frontiers in Genetics, 2021 - frontiersin.org
Primary ovarian insufficiency (POI) is a clinical spectrum of ovarian dysfunction. Overt POI
presents with oligo/amenorrhea and hypergonadotropic hypogonadism before age 40 …

miR-125b contributes to ovarian granulosa cell apoptosis through targeting BMPR1B, a major gene for sheep prolificacy

Y Yao, A Reheman, Y Xu, Q Li - Reproductive Sciences, 2019 - journals.sagepub.com
Bone morphogenetic protein receptor 1B (BMPR1B) is a major gene for ovine ovulation rate
and litter size, which plays a crucial role in follicle development. However, its role and …

[图书][B] The ovary

PCK Leung, EY Adashi - 2018 - books.google.com
The Ovary, Third Edition, includes more than 60% new material that highlights the clinical
aspects of human ovarian functions. It covers advances in the areas of genomics, assisted …

Molecular mechanism of FSHR expression induced by BMP15 in human granulosa cells

K Shimizu, T Nakamura, Bayasula, N Nakanishi… - Journal of Assisted …, 2019 - Springer
Purpose Follicle-stimulating hormone receptor (FSHR) expression in granulosa cells is
critical in enabling follicles to achieve accelerated growth. Although FSHR expression has …

Serum concentrations of oocyte-secreted factors BMP15 and GDF9 during IVF and in women with reproductive pathologies

AH Riepsamen, K Chan, S Lien, P Sweeten… - …, 2019 - academic.oup.com
Oocyte-secreted factors bone morphogenetic protein 15 (BMP15) and growth differentiation
factor 9 (GDF9) are critical for folliculogenesis and fertility. This study developed ELISAs for …

Detection of single nucleotide polymorphisms at major prolificacy genes in the Mehraban sheep and association with litter size

R Talebi, A Ahmadi, F Afraz, J Sarry… - Annals of Animal …, 2018 - sciendo.com
1Department of Animal Sciences, Faculty of Agriculture, Bu-Ali Sina University, Hamedan,
Iran 2Department of Livestock and Aquaculture Biotechnology, Agricultural Biotechnology …

[PDF][PDF] Progress on major genes for high fecundity in ewes

Q Liu, Z Pan, X Wang, W Hu, R Di… - Front. Agric. Sci …, 2014 - pdfs.semanticscholar.org
The existence of major genes affecting fecundity in sheep flocks throughout the world has
been demonstrated. Three major genes whose mutations can increase ovulation rate have …