AlphaFold2 and its applications in the fields of biology and medicine
Z Yang, X Zeng, Y Zhao, R Chen - Signal Transduction and Targeted …, 2023 - nature.com
Abstract AlphaFold2 (AF2) is an artificial intelligence (AI) system developed by DeepMind
that can predict three-dimensional (3D) structures of proteins from amino acid sequences …
that can predict three-dimensional (3D) structures of proteins from amino acid sequences …
Intrinsically disordered proteins play diverse roles in cell signaling
Signaling pathways allow cells to detect and respond to a wide variety of chemical (eg Ca2+
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …
or chemokine proteins) and physical stimuli (eg, sheer stress, light). Together, these …
Highly accurate protein structure prediction for the human proteome
Protein structures can provide invaluable information, both for reasoning about biological
processes and for enabling interventions such as structure-based drug development or …
processes and for enabling interventions such as structure-based drug development or …
Accurate prediction of protein structures and interactions using a three-track neural network
DeepMind presented notably accurate predictions at the recent 14th Critical Assessment of
Structure Prediction (CASP14) conference. We explored network architectures that …
Structure Prediction (CASP14) conference. We explored network architectures that …
flDPnn: Accurate intrinsic disorder prediction with putative propensities of disorder functions
G Hu, A Katuwawala, K Wang, Z Wu… - Nature …, 2021 - nature.com
Identification of intrinsic disorder in proteins relies in large part on computational predictors,
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome
KS Robinson, GA Toh, P Rozario, R Chua… - Science, 2022 - science.org
Human NLRP1 (NACHT, LRR, and PYD domain-containing protein 1) is an innate immune
sensor predominantly expressed in the skin and airway epithelium. Here, we report that …
sensor predominantly expressed in the skin and airway epithelium. Here, we report that …
BioSeq-BLM: a platform for analyzing DNA, RNA and protein sequences based on biological language models
In order to uncover the meanings of 'book of life', 155 different biological language models
(BLMs) for DNA, RNA and protein sequence analysis are discussed in this study, which are …
(BLMs) for DNA, RNA and protein sequence analysis are discussed in this study, which are …
[PDF][PDF] Metapredict: a fast, accurate, and easy-to-use predictor of consensus disorder and structure
Intrinsically disordered proteins and protein regions make up a substantial fraction of many
proteomes in which they play a wide variety of essential roles. A critical first step in …
proteomes in which they play a wide variety of essential roles. A critical first step in …
Rapid prediction and analysis of protein intrinsic disorder
GW Dayhoff, VN Uversky - Protein Science, 2022 - Wiley Online Library
Protein intrinsic disorder is found in all kingdoms of life and is known to underpin numerous
physiological and pathological processes. Computational methods play an important role in …
physiological and pathological processes. Computational methods play an important role in …
AlphaFold2: a role for disordered protein/region prediction?
The development of AlphaFold2 marked a paradigm-shift in the structural biology
community. Herein, we assess the ability of AlphaFold2 to predict disordered regions …
community. Herein, we assess the ability of AlphaFold2 to predict disordered regions …