Receptor-binding domain-specific human neutralizing monoclonal antibodies against SARS-CoV and SARS-CoV-2
F Yu, R Xiang, X Deng, L Wang, Z Yu, S Tian… - … and Targeted Therapy, 2020 - nature.com
The outbreaks of severe acute respiratory syndrome (SARS) and Coronavirus Disease 2019
(COVID-19) caused by SARS-CoV and SARS-CoV-2, respectively, have posed severe …
(COVID-19) caused by SARS-CoV and SARS-CoV-2, respectively, have posed severe …
Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses
To address the ongoing SARS-CoV-2 pandemic and prepare for future coronavirus
outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV …
outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV …
Fruitful neutralizing antibody pipeline brings hope to defeat SARS-Cov-2
With the recent spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2) _
infecting> 16 million people worldwide as of 28 July 2020, causing> 650 000 deaths, there …
infecting> 16 million people worldwide as of 28 July 2020, causing> 650 000 deaths, there …
[HTML][HTML] Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2
A safe, effective, and scalable vaccine is needed to halt the ongoing SARS-CoV-2
pandemic. We describe the structure-based design of self-assembling protein nanoparticle …
pandemic. We describe the structure-based design of self-assembling protein nanoparticle …
Is the rigidity of SARS-CoV-2 spike receptor-binding motif the hallmark for its enhanced infectivity? Insights from all-atom simulations
A Spinello, A Saltalamacchia… - The journal of physical …, 2020 - ACS Publications
The severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic is setting the
global health crisis of our time, causing a devastating societal and economic burden. An …
global health crisis of our time, causing a devastating societal and economic burden. An …
[HTML][HTML] Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike
Memory B cell reserves can generate protective antibodies against repeated SARS-CoV-2
infections, but with unknown reach from original infection to antigenically drifted variants. We …
infections, but with unknown reach from original infection to antigenically drifted variants. We …
Potential for developing a SARS-CoV receptor-binding domain (RBD) recombinant protein as a heterologous human vaccine against coronavirus infectious disease …
ABSTRACT A SARS-CoV receptor-binding domain (RBD) recombinant protein was
developed and manufactured under current good manufacturing practices in 2016. The …
developed and manufactured under current good manufacturing practices in 2016. The …
[HTML][HTML] Neutralizing antibody and soluble ACE2 inhibition of a replication-competent VSV-SARS-CoV-2 and a clinical isolate of SARS-CoV-2
Antibody-based interventions against SARS-CoV-2 could limit morbidity, mortality, and
possibly transmission. An anticipated correlate of such countermeasures is the level of …
possibly transmission. An anticipated correlate of such countermeasures is the level of …
Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies
Antibody therapeutics and vaccines are among our last resort to end the raging COVID-19
pandemic. They, however, are prone to over 5000 mutations on the spike (S) protein …
pandemic. They, however, are prone to over 5000 mutations on the spike (S) protein …
[HTML][HTML] Neutralization of SARS-CoV-2 by destruction of the prefusion spike
There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal
coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding …
coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor binding …