Major depressive disorder (MDD) is a debilitating illness characterized by neuroanatomical
and functional alterations in limbic structures, notably the prefrontal cortex (PFC), that can be …

An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

Major depressive disorder (MDD) is a leading cause of disease burden worldwide. While the
incidence, symptoms and treatment of MDD all point toward major sex differences, the …

This paper is the first review into the automatic analysis of speech for use as an objective
predictor of depression and suicidality. Both conditions are major public health concerns; …

Cognitive dysfunctions, including impaired attention, learning, memory, planning and
problem solving, occur in depressive episodes, often persist during remission, predict …

Increasing evidence points to an association between major depressive disorders (MDDs)
and diverse types of GABAergic deficits. In this review, we summarize clinical and preclinical …

Context Our genome adapts to environmental influences, in part through epigenetic
mechanisms, including DNA methylation. Variations in the quality of the early environment …

Major depressive disorder (MDD) is a prevalent mood disorder that is associated with
differential prefrontal brain expression patterns. Treatment of MDD includes a variety of …

The etiology of major depression (MDD), a common and complex disorder, remains
obscure. Gene expression profiling was conducted on post-mortem brain tissue samples …

Brain gene expression profiling studies of suicide and depression using oligonucleotide
microarrays have often failed to distinguish these two phenotypes. Moreover, next …