[HTML][HTML] Aurora kinase B inhibition: a potential therapeutic strategy for cancer
NA Borah, MM Reddy - Molecules, 2021 - mdpi.com
Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the
aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC) …
aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC) …
Impact of emerging pollutant florfenicol on enhanced biological phosphorus removal process: Focus on reactor performance and related mechanisms
Q Yuan, H Zhang, C Qin, H Zhang, D Wang… - Science of the Total …, 2023 - Elsevier
Florfenicol (FF), an emerging pollutant antibiotic that is difficult to biodegrade, inevitably
enters sewage treatment facilities with high level. To date, however, the performance and …
enters sewage treatment facilities with high level. To date, however, the performance and …
FMS-like tyrosine kinase-3 (FLT3) inhibitors with better binding affinity and ADMET properties than sorafenib and gilteritinib against acute myeloid leukemia: in silico …
C Egbuna, KC Patrick-Iwuanyanwu… - Journal of …, 2022 - Taylor & Francis
Abstract Over 30–35% of patients down with AML are caused by mutations of FLT3‐ITD and
FLT3‐TKD which keeps the protein activated while it activates other signaling proteins …
FLT3‐TKD which keeps the protein activated while it activates other signaling proteins …
AML treatment: conventional chemotherapy and emerging novel agents
M Forsberg, M Konopleva - Trends in Pharmacological Sciences, 2024 - cell.com
Acute myeloid leukemia (AML) is driven by complex mutations and cytogenetic
abnormalities with profound tumoral heterogeneity, making it challenging to treat. Ten years …
abnormalities with profound tumoral heterogeneity, making it challenging to treat. Ten years …
Effects of antibiotics on enhanced biological phosphorus removal and its mechanisms
L Wu, Q Wei, Y Zhang, Y Fan, M Li, L Rong… - Science of the Total …, 2021 - Elsevier
Many kinds of antibiotics are continuously discharged into wastewater and typically cause a
great decrease in sewage treatment performance, whereas mechanisms of differences in …
great decrease in sewage treatment performance, whereas mechanisms of differences in …
Vital role of CYP450 in the biodegradation of antidiabetic drugs in the aerobic activated sludge system and the mechanisms
L Wu, H Luo, J Xu, L Yu, J Xiong, Y Liu, X Huang… - Journal of Hazardous …, 2024 - Elsevier
The extensive use of antidiabetic drugs (ADDs) and their detection in high concentrations in
the environment have been extensively documented. However, the mechanism of ADDs …
the environment have been extensively documented. However, the mechanism of ADDs …
Identification of potent small-molecule PCSK9 inhibitors based on quantitative structure-activity relationship, pharmacophore modeling, and molecular docking …
The leading cause of atherosclerotic cardiovascular disease (ASCVD) is elevated low-
density lipoprotein cholesterol (LDL-C). Proprotein convertase subtilisin/kexin type 9 …
density lipoprotein cholesterol (LDL-C). Proprotein convertase subtilisin/kexin type 9 …
A Simple Machine Learning-Based Quantitative Structure-Activity Relationship Model for Predicting pIC50 Inhibition Values of FLT3 Tyrosine Kinase
JJ Alcázar, I Sánchez, C Merino, B Monasterio… - 2024 - preprints.org
In this study, a simple machine learning-based quantitative structure-activity relationship
(QSAR) model was developed to predict the inhibitory potency (pIC50 values) of FLT3 …
(QSAR) model was developed to predict the inhibitory potency (pIC50 values) of FLT3 …