Drug affinity responsive target stability (DARTS) is a novel target discovery approach and is
particularly adept at screening small molecule (SM) targets without requiring any structural …

Early and prompt reperfusion therapy has markedly improved the survival rates among
patients enduring myocardial infarction (MI). Nonetheless, the resulting adverse remodeling …

Myocardial infarction (MI) resulting from coronary artery occlusion is the leading global
cause of cardiovascular disability and mortality. Anti-inflammatory treatment plays an …

Introduction Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease all
over the world, and no drug is approved for the treatment of NAFLD. Bavachinin (BVC) is …

Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is a disabling disease
with high mortality in China but the detailed molecular and cellular mechanisms remain to …

Objective Although many works have been done, the objectively measured diagnostic
biomarkers are not available. Thus, we conducted this study to identify potential biomarkers …

Cardiovascular disease (CVD) is a major threat to human health, accounting for 46% of non-
communicable disease deaths. Glycolysis is a conserved and rigorous biological process …

Rescuing endothelial cells from pyroptotic cell death emerges as a potential therapeutic
strategy to combat diabetic atherosclerosis. Salvianolic acid A (SAA) is a major water …

The gut microbiome has emerged as a crucial player in developing and progressing
cardiovascular diseases (CVDs). Recent studies have highlighted the role of microbial …

Cardiovascular diseases (CVDs) are the leading cause of hospitalization and death
worldwide, especially in developing countries. The increased prevalence rate and mortality …