Mechanochemistry: new tools to navigate the uncharted territory of “impossible” reactions

F Cuccu, L De Luca, F Delogu, E Colacino… - …, 2022 - Wiley Online Library
Mechanochemical transformations have made chemists enter unknown territories, forcing a
different chemistry perspective. While questioning or revisiting familiar concepts belonging …

Microfabrication of peptide self-assemblies: inspired by nature towards applications

J Zhang, Y Wang, BJ Rodriguez, R Yang… - Chemical Society …, 2022 - pubs.rsc.org
Peptide self-assemblies show intriguing and tunable physicochemical properties, and thus
have been attracting increasing interest over the last two decades. However, the micro/nano …

[HTML][HTML] Food amyloid fibrils are safe nutrition ingredients based on in-vitro and in-vivo assessment

D Xu, J Zhou, WL Soon, I Kutzli, A Molière… - Nature …, 2023 - nature.com
Food protein amyloid fibrils have superior technological, nutritional, sensorial, and physical
properties compared to native monomers, but there is as yet insufficient understanding of …

Dynamic intracellular exchange of nanomaterials' protein corona perturbs proteostasis and remodels cell metabolism

R Cai, J Ren, M Guo, T Wei, Y Liu… - Proceedings of the …, 2022 - National Acad Sciences
The nanomaterial–protein “corona” is a dynamic entity providing a synthetic–natural
interface mediating cellular uptake and subcellular distribution of nanomaterials in biological …

[HTML][HTML] Synthesis of a glycan hairpin

G Fittolani, T Tyrikos-Ergas, A Poveda, Y Yu… - Nature Chemistry, 2023 - nature.com
The primary sequence of a biopolymer encodes the essential information for folding,
permitting to carry out sophisticated functions. Inspired by natural biopolymers, peptide and …

[HTML][HTML] Endothelial leakiness elicited by amyloid protein aggregation

Y Li, N Ni, M Lee, W Wei, N Andrikopoulos… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) is a major cause of dementia debilitating the global ageing
population. Current understanding of the AD pathophysiology implicates the aggregation of …

A central role for amyloid fibrin microclots in long COVID/PASC: origins and therapeutic implications

DB Kell, GJ Laubscher, E Pretorius - Biochemical Journal, 2022 - portlandpress.com
Post-acute sequelae of COVID (PASC), usually referred to as 'Long COVID'(a phenotype of
COVID-19), is a relatively frequent consequence of SARS-CoV-2 infection, in which …

[HTML][HTML] Orchestration of selective autophagy by cargo receptors

E Adriaenssens, L Ferrari, S Martens - Current Biology, 2022 - cell.com
Cellular homeostasis requires the swift and specific removal of damaged material. Selective
autophagy represents a major pathway for the degradation of such cargo material. This is …

[HTML][HTML] Multipronged diagnostic and therapeutic strategies for Alzheimer's disease

M Ramesh, T Govindaraju - Chemical science, 2022 - pubs.rsc.org
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major
contributor to dementia cases worldwide. AD is clinically characterized by learning, memory …

[HTML][HTML] Common transthyretin-derived amyloid fibril structures in patients with hereditary ATTR amyloidosis

M Steinebrei, J Baur, A Pradhan, N Kupfer… - Nature …, 2023 - nature.com
Systemic ATTR amyloidosis is an increasingly important protein misfolding disease that is
provoked by the formation of amyloid fibrils from transthyretin protein. The pathological and …