Regulatory T cells (Tregs) and COVID-19: unveiling the mechanisms, and therapeutic potentialities with a special focus on long COVID

M Dhawan, AA Rabaan, S Alwarthan, M Alhajri… - Vaccines, 2023 - mdpi.com
The COVID-19 pandemic has caused havoc all around the world. The causative agent of
COVID-19 is the novel form of the coronavirus (CoV) named SARS-CoV-2, which results in …

Eosinophils as potential biomarkers in respiratory viral infections

I Macchia, V La Sorsa, F Urbani, S Moretti… - Frontiers in …, 2023 - frontiersin.org
Eosinophils are bone marrow-derived granulocytes that, under homeostatic conditions,
account for as much as 1-3% of peripheral blood leukocytes. During inflammation …

Liquid biomarkers of macrophage dysregulation and circulating spike protein illustrate the biological heterogeneity in patients with post‐acute sequelae of COVID‐19

C Schultheiß, E Willscher, L Paschold… - Journal of Medical …, 2023 - Wiley Online Library
Post‐acute sequelae of COVID‐19 (PASC) are long‐term consequences of SARS‐CoV‐2
infection that can substantially impair the quality of life. Underlying mechanisms ranging …

Potential for early noninvasive COVID-19 detection using electronic-nose technologies and disease-specific VOC metabolic biomarkers

AD Wilson, LB Forse - Sensors, 2023 - mdpi.com
The established efficacy of electronic volatile organic compound (VOC) detection
technologies as diagnostic tools for noninvasive early detection of COVID-19 and related …

Inhibition of the mitochondrial pyruvate carrier simultaneously mitigates hyperinflammation and hyperglycemia in COVID-19

B Zhu, X Wei, H Narasimhan, W Qian, R Zhang… - Science …, 2023 - science.org
The relationship between diabetes and coronavirus disease 2019 (COVID-19) is
bidirectional: Although individuals with diabetes and high blood glucose (hyperglycemia) …

Pathophysiological, immunological, and inflammatory features of long COVID

K Bohmwald, B Diethelm-Varela… - Frontiers in …, 2024 - frontiersin.org
The COVID-19 pandemic continues to cause severe global disruption, resulting in significant
excess mortality, overwhelming healthcare systems, and imposing substantial social and …

Aggregate Index of Systemic Inflammation (AISI), Disease Severity, and Mortality in COVID-19: A Systematic Review and Meta-Analysis

A Zinellu, P Paliogiannis, AA Mangoni - Journal of Clinical Medicine, 2023 - mdpi.com
Combined indices of different haematological cell types appear to be particularly promising
for investigating the link between systemic inflammation and coronavirus disease 2019 …

A pictorial essay describing the CT imaging features of COVID-19 cases throughout the pandemic with a special focus on lung manifestations and extrapulmonary …

B Brogna, E Bignardi, A Megliola, A Laporta… - Biomedicines, 2023 - mdpi.com
With the Omicron wave, SARS-CoV-2 infections improved, with less lung involvement and
few cases of severe manifestations. In this pictorial review, there is a summary of the …

Molecular and immune signatures, and pathological trajectories of fatal COVID‐19 lungs defined by in situ spatial single‐cell transcriptome analysis

A Das, W Meng, Z Liu, MM Hasib… - Journal of Medical …, 2023 - Wiley Online Library
Despite intensive studies during the last 3 years, the pathology and underlying molecular
mechanism of coronavirus disease 2019 (COVID‐19) remain poorly defined. In this study …

The knowns and unknowns of long COVID-19: from mechanisms to therapeutical approaches

R Gheorghita, I Soldanescu, A Lobiuc… - Frontiers in …, 2024 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has been
defined as the greatest global health and socioeconomic crisis of modern times. While most …