Uracil is one of the most notable pharmacophores in medicinal chemistry as the pyrimidine
nucleobase forms an integral part of many commercial drugs. Though the name uracil is …

Purines and pyrimidines are essential nutrients for any cell. Most organisms are able to
synthesize their own purines and pyrimidines, but this ability was lost in protozoans that …

Trypanosomiasis and leishmaniasis are a group of neglected parasitic diseases caused by
several species of parasites belonging to the family Trypansomatida. The present study …

Schistosomes are responsible for the parasitic disease schistosomiasis, an acute and
chronic parasitic ailment that affects> 240 million people in 70 countries worldwide. It is the …

Trichomoniasis is the most common nonviral sexually transmitted disease in humans, but
treatment options are limited. Here, we report a resorufin-based drug sensitivity assay for …

Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial
therapies. Recent results from our laboratories from two structurally related scaffolds have …

A simple and efficient one-pot multicomponent solvent-free protocol developed for the
synthesis of 3, 4-dihydropyrimidine-2-one derivatives from the reaction of various aromatic …

An adequate enhancement in the development of resistance by microbial pathogens against
the available chemotherapeutic agents prompted us to find out some new chemotherapeutic …

A series of fifteen (Z)-N-substituted-4-(pyridin-2-yl)-6-(1 H-pyrrolo [2, 3-b] pyridin-4-yl)
pyrimidin-2-amine, was designed, screened computationally and synthesized. Structures of …

A series of fifteen 2-substituted-3-(4-(pyridin-2-yl)-6-(1 H-pyrrolo [2, 3-b] pyridin-4-yl)
pyrimidin-2-yl) thiazolidin-4-one, was prepared and characterized using analytical …