The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Cell type-and differentiation-specific gene expression is precisely controlled by genomic non-
coding regulatory elements (NCREs), which include promoters, enhancers, silencers and …

Understanding gene function and regulation in homeostasis and disease requires
knowledge of the cellular and tissue contexts in which genes are expressed. Here, we …

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

Chickens are the most common birds on Earth and colibacillosis is among the most common
diseases affecting them. This major threat to animal welfare and safe sustainable food …

Over the past 15 years, genome-wide association studies (GWASs) have generated a
wealth of new information. Larger samples sizes, refined phenotypes and higher-resolution …

Understanding cellular heterogeneity is the holy grail of biology and medicine. Cells
harboring identical genomes show a wide variety of behaviors in multicellular organisms …

The emergence and spread of artemisinin-resistant Plasmodium falciparum, first in the
Greater Mekong Subregion (GMS), and now in East Africa, is a major threat to global malaria …

Regulatory elements activate promoters by recruiting transcription factors (TFs) to specific
motifs. Notably, TF-DNA interactions often depend on cooperativity with colocalized …

Interpreting the molecular mechanism of genomic variations and their causal relationship
with diseases/traits are important and challenging problems in the human genetic study. To …