Understanding the role of SARS-CoV-2 ORF3a in viral pathogenesis and COVID-19
J Zhang, A Ejikemeuwa, V Gerzanich, M Nasr… - Frontiers in …, 2022 - frontiersin.org
The ongoing SARS-CoV-2 pandemic has shocked the world due to its persistence, COVID-
19-related morbidity and mortality, and the high mutability of the virus. One of the major …
19-related morbidity and mortality, and the high mutability of the virus. One of the major …
Stopping pandemics before they start: Lessons learned from SARS-CoV-2
AM Edwards, RS Baric, EO Saphire, JB Ulmer - Science, 2022 - science.org
The vaccine and drug discovery responses to COVID-19 have worked far better than could
have been imagined. Yet by the end of 2021, more than 5 million people had died, and the …
have been imagined. Yet by the end of 2021, more than 5 million people had died, and the …
Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants
TS Johnston, SH Li, MM Painter, RK Atkinson… - Immunity, 2024 - cell.com
The spike glycoprotein of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)
continues to accumulate substitutions, leading to breakthrough infections of vaccinated …
continues to accumulate substitutions, leading to breakthrough infections of vaccinated …
Research progress in spike mutations of SARS‐CoV‐2 variants and vaccine development
X He, C He, W Hong, J Yang… - Medicinal Research …, 2023 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic can hardly end with the
emergence of different variants over time. In the past 2 years, several variants of severe …
emergence of different variants over time. In the past 2 years, several variants of severe …
Development of functionally relevant potency assays for monovalent and multivalent vaccines delivered by evolving technologies
G Sanyal - npj Vaccines, 2022 - nature.com
A potency or potency-indicating assay is a regulatory requirement for the release of every lot
of a vaccine. Potency is a critical quality attribute that is also monitored as a stability indicator …
of a vaccine. Potency is a critical quality attribute that is also monitored as a stability indicator …
Ecological and evolutionary dynamics of multi-strain RNA viruses
Potential interactions among co-circulating viral strains in host populations are often
overlooked in the study of virus transmission. However, these interactions probably shape …
overlooked in the study of virus transmission. However, these interactions probably shape …
Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants
The rapid evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron variants has emphasized the need to identify antibodies with broad neutralizing …
Omicron variants has emphasized the need to identify antibodies with broad neutralizing …
Impact of the double mutants on spike protein of SARS-CoV-2 B. 1.617 lineage on the human ACE2 receptor binding: A structural insight
The recent emergence of novel SARS-CoV-2 variants has threatened the efforts to contain
the COVID-19 pandemic. The emergence of these “variants of concern” has increased …
the COVID-19 pandemic. The emergence of these “variants of concern” has increased …
Serum Fc-mediated monocyte phagocytosis activity is stable for several months after SARS-CoV-2 asymptomatic and mildly symptomatic infection
S Vangeti, S Periasamy, P Sun, CA Balinsky… - Microbiology …, 2022 - Am Soc Microbiol
We investigated the temporal profile of multiple components of the serological response
after asymptomatic or mildly symptomatic SARS-CoV-2 infection, in a cohort of 67 previously …
after asymptomatic or mildly symptomatic SARS-CoV-2 infection, in a cohort of 67 previously …
[HTML][HTML] Cross-variant protection against SARS-CoV-2 infection in hamsters immunized with monovalent and bivalent inactivated vaccines
Rapid development and successful use of vaccines against SARS-CoV-2 might hold the key
to curb the ongoing pandemic of COVID-19. Emergence of vaccine-evasive SARS-CoV-2 …
to curb the ongoing pandemic of COVID-19. Emergence of vaccine-evasive SARS-CoV-2 …