Osteoarthritis comprises several joint disorders characterized by articular cartilage
degeneration and persistent pain, causing disability and economic burden. The incidence of …

Osteoporotic fractures lead to increased disability and mortality in the elderly population.
With the rapid increase in the aging population around the globe, more effective treatments …

The integration of structure and function for tissue engineering scaffolds is of great
importance in mimicking native bone tissue. However, the complexity of hierarchical …

Angiogenesis and neurogenesis play irreplaceable roles in bone repair. Although
biomaterial implantation that mimics native skeletal tissue is extensively studied, the nerve …

INTRODUCTION Currently there are no approved treatments for sarcopenia, the age-
dependent loss of skeletal muscle mass and strength that constitutes a major public health …

Neural‐vascular networks are densely distributed through periosteum, cortical bone, and
cancellous bone, which is of great significance for bone regeneration and remodeling …

Limited motor activity due to the loss of natural structure impedes recovery in patients
suffering from tendon-to-bone injury. Conventional biomaterials focus on strengthening the …

Skeletal tissue is highly innervated. Although different types of nerves have been recently
identified in the bone, the crosstalk between bone and nerves remains unclear. In this …

For the past two decades, the function of intrabony nerves on bone has been a subject of
intense research, while the function of bone on intrabony nerves is still hidden in the corner …

Recent studies have determined that the nervous system can sense and respond to signals
from skeletal tissue, a process known as skeletal interoception, which is crucial for …