Embryonic differentiation programs of epithelial–mesenchymal and mesenchymal–epithelial
transition (EMT and MET) represent a mechanistic basis for epithelial cell plasticity …

Metabolic reprogramming has been described in rapidly growing tumors, which are thought
to mostly contain fast‐cycling cells (FCC s) that have impaired mitochondrial function and …

The development of metastases is the main reason for cancer-related death in non–small
cell lung cancer (NSCLC). The initiation of metastasis involves an increase in cell motility …

The process of epithelial to mesenchymal transition (EMT), first noted during
embryogenesis, has also been reported in tumor formation and leads to the development of …

The adenosine triphosphate (ATP)-binding cassette efflux transporter G2 (ABCG2) was
originally discovered in a multidrug-resistant breast cancer cell line. Studies in the past have …

Aberrant regulation of Wnt signaling is a common theme seen across many tumor types.
Decades of research have unraveled the epigenetic and genetic alterations that result in …

Numerous studies have demonstrated the presence of cancer stem cells (CSCs) within solid
tumors. Although the precursor of these cells is not clearly established, recent studies …

In recent years, increasing biological experiments and scientific studies have demonstrated
that microRNA (miRNA) plays an important role in the development of human complex …

Germ‐line mutations in the BRCA1 gene strongly predispose women to breast cancer
(lifetime risk up to 80%). Furthermore, the BRCA1 protein is absent or present at very low …

MicroRNAs (miRNAs) are short non-coding RNAs that regulate the function of target genes
at the post-transcriptional phase. miRNAs are considered to have roles in the development …