Objectives MicroRNAs (miRNAs) are a type of small noncoding RNA employed by the cells
for gene regulation. A single miRNA, typically 22 nucleotides in length, can regulate the …

MicroRNAs have a revolutionary impact on cancer research over recent years. They emerge
as important players in tumorigenesis, leading to a paradigm shift in oncology. The …

MicroRNAs (miRNAs) are a major class of small endogenous RNA molecules that post-
transcriptionally inhibit gene expression. Many miRNAs have been implicated in several …

Breast cancer is one of the most frequent malignancies among women worldwide. Methods
for screening and diagnosis allow health care professionals to provide personalized …

There is compelling evidence that many solid cancers are organized hierarchically and
contain a small population of cancer stem cells (CSCs). It seems reasonable to suggest that …

Stem cells have self-renewal capacities and the ability to give rise to differentiated cells
thereby sustaining tissues during homeostasis and injury. This structural hierarchy extends …

The release of circulating tumor cells (CTCs) into vasculature is an early event in the
metastatic process. The analysis of CTCs in patients has recently received widespread …

Paclitaxel (Taxol) is an effective chemotherapeutic agent for treatment of cancer patients.
Despite impressive initial clinical responses, the majority of patients eventually develop …

Notch signalling is important for development and tissue homeostasis and activated in many
human cancers. Nevertheless, mutations in Notch pathway components are rare in solid …

Cancer stem cells (CSCs) are cells within a tumor that possess the capacity to self-renew
and maintain tumor-initiating capacity through differentiation into the heterogeneous …