The use of artificial intelligence, and the deep-learning subtype in particular, has been
enabled by the use of labeled big data, along with markedly enhanced computing power …

Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins
and RNA. The methylation of chromatin components is highly conserved as it helps …

A substantial proportion of disease risk for common complex disorders is attributable to
environmental exposures and pollutants. An appreciation of how environmental pollutants …

Ageing is inherent to all human beings, yet why we age remains a hotly contested topic.
Most mechanistic explanations of ageing posit that ageing is caused by the accumulation of …

Epigenetic “clocks” can now surpass chronological age in accuracy for estimating biological
age. Here, we use four such age estimators to show that epigenetic aging can be reversed …

Biomarkers developed from DNA methylation (DNAm) data are of growing interest as
predictors of health outcomes and mortality in older populations. However, it is unknown …

As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

The geroscience hypothesis proposes that therapy to slow or reverse molecular changes
that occur with aging can delay or prevent multiple chronic diseases and extend healthy …