[HTML][HTML] Immune responses in mildly versus critically ill COVID-19 patients

H Nasrollahi, AG Talepoor, Z Saleh… - Frontiers in …, 2023 - frontiersin.org
The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had
devastating effects on the global health and economic system. The cellular and molecular …

Pathogenesis‐directed therapy of 2019 novel coronavirus disease

CW Stratton, YW Tang, H Lu - Journal of medical virology, 2021 - Wiley Online Library
The 2019 novel coronavirus disease (COVID‐19) now is considered a global public health
emergency. One of the unprecedented challenges is defining the optimal therapy for those …

Transport by circulating myeloid cells drives liposomal accumulation in inflamed synovium

J Deprez, R Verbeke, S Meulewaeter, I Aernout… - Nature …, 2023 - nature.com
The therapeutic potential of liposomes to deliver drugs into inflamed tissue is well
documented. Liposomes are believed to largely transport drugs into inflamed joints by …

[HTML][HTML] Dynamic alterations in monocyte numbers, subset frequencies and activation markers in acute and convalescent COVID-19 individuals

A Rajamanickam, NP Kumar, AN Pandiarajan… - Scientific reports, 2021 - nature.com
Monocytes are thought to play an important role in host defence and pathogenesis of COVID-
19. However, a comprehensive examination of monocyte numbers and function has not …

COVID-19 myocarditis: quantitative analysis of the inflammatory infiltrate and a proposed mechanism

SE Fox, L Falgout, RS Vander Heide - Cardiovascular Pathology, 2021 - Elsevier
COVID-19 has a significant effect upon the cardiovascular system. While a number of
different cardiovascular histopathologies have been described at post-mortem examination …

Amino acid metabolism is significantly altered at the time of admission in hospital for severe COVID-19 patients: findings from longitudinal targeted metabolomics …

L Ansone, M Briviba, I Silamikelis… - Microbiology …, 2021 - Am Soc Microbiol
The heterogeneity in severity and outcome of COVID-19 cases points out the urgent need for
early molecular characterization of patients followed by risk-stratified care. The main …

[HTML][HTML] SARS-CoV-2: is there neuroinvasion?

C McQuaid, M Brady, R Deane - Fluids and Barriers of the CNS, 2021 - Springer
Abstract Background SARS-CoV-2, a coronavirus (CoV), is known to cause acute respiratory
distress syndrome, and a number of non-respiratory complications, particularly in older male …

[HTML][HTML] Context-aware deconvolution of cell–cell communication with Tensor-cell2cell

E Armingol, HM Baghdassarian, C Martino… - Nature …, 2022 - nature.com
Cell interactions determine phenotypes, and intercellular communication is shaped by
cellular contexts such as disease state, organismal life stage, and tissue microenvironment …

[HTML][HTML] Antibody-independent functions of B cells during viral infections

V Upasani, I Rodenhuis-Zybert, T Cantaert - PLoS pathogens, 2021 - journals.plos.org
The humoral immune response and antibody-mediated functions of B cells during viral
infections are well described. However, we have limited understanding of antibody …

[HTML][HTML] The role of lung macrophages in acute respiratory distress syndrome

W Dang, Y Tao, X Xu, H Zhao, L Zou, Y Li - Inflammation Research, 2022 - Springer
Acute respiratory distress syndrome (ARDS) is an acute and diffuse inflammatory lung injury
in a short time, one of the common severe manifestations of the respiratory system that …