[HTML][HTML] On deep landscape exploration of COVID-19 patients cells and severity markers

A Vázquez-Jiménez, UE Avila-Ponce De Leon… - Frontiers in …, 2021 - frontiersin.org
COVID-19 is a disease with a spectrum of clinical responses ranging from moderate to
critical. To study and control its effects, a large number of researchers are focused on two …

Unifying considerations and evidence of macrophage activation mosaicism through human CSF1R and M1/M2 genes

F Orsenigo, A Stewart, CP Hammer, E Clarke… - Cell Reports, 2024 - cell.com
Addressing the mononuclear phagocyte system (MPS) and macrophage M1/M2 activation is
important in diagnosing hematological disorders and inflammatory pathologies and …

Bystander effect of SARS-CoV-2 spike protein on human monocytic THP-1 cell activation and initiation of prothrombogenic stimulus representing severe COVID-19

T Patra, R Ray - Journal of Inflammation, 2022 - Springer
Background Hypercoagulable state and thromboembolic complications are potential life-
threatening events in COVID-19 patients. Our previous studies demonstrated that SARS …

[HTML][HTML] Age and comorbidities predict COVID-19 outcome, regardless of innate immune response severity: A single institutional cohort study

AA Mohan, LB Olson, IA Naqvi… - Critical Care …, 2022 - journals.lww.com
OBJECTIVES: The COVID-19 pandemic has claimed over eight hundred thousand lives in
the United States alone, with older individuals and those with comorbidities being at higher …

Linking COVID-19, monocyte activation and sepsis: MDW, a novel biomarker from cytometry

G Riva, V Nasillo, M Luppi, E Tagliafico, T Trenti - EBioMedicine, 2022 - thelancet.com
Circulating monocytes, recruited from the bone marrow to injured organs upon infection or
tissue damage, stay at the complex intersection of immune defence, systemic inflammation …

Anti-correlated feature selection prevents false discovery of subpopulations in scRNAseq

SR Tyler, D Lozano-Ojalvo, E Guccione… - Nature …, 2024 - nature.com
While sub-clustering cell-populations has become popular in single cell-omics, negative
controls for this process are lacking. Popular feature-selection/clustering algorithms fail the …

Reduced Reliability of Procalcitonin (PCT) as a Biomarker of Bacterial Superinfection: Concerns about PCT-Driven Antibiotic Stewardship in Critically Ill COVID-19 …

G Ceccarelli, F Alessandri, G Migliara… - Journal of Clinical …, 2023 - mdpi.com
Background: The aim of this study was to assess whether procalcitonin levels is a diagnostic
tool capable of accurately identifying sepsis and ventilator-associated pneumonia (VAP) …

Is procalcitonin a part of human immunological response to SARS-CoV-2 infection or “just” a marker of bacterial coinfection?

NPH Lugito - Current Research in Translational Medicine, 2021 - Elsevier
Elevated PCT level in COVID-19 was associated with higher risk of severe disease and
higher risk of overall mortality. An increased PCT level of PCT in COVID-19 patients …

Thrombocytopenia in COVID‑19 and vaccine‑induced thrombotic thrombocytopenia

SA Geronikolou, I Takan… - International …, 2022 - spandidos-publications.com
The highly heterogeneous symptomatology and unpredictable progress of COVID‑19
triggered unprecedented intensive biomedical research and a number of clinical research …

Monocyte anisocytosis corresponds with increasing severity of COVID-19 in children

AS Kane, BP Boribong, M Loiselle, AP Chitnis… - Frontiers in …, 2023 - frontiersin.org
Introduction Although SARS-CoV-2 infection can lead to severe COVID-19 in children, the
role of biomarkers for assessing the risk of progression to severe disease is not well …